Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-15
2006-08-15
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07090986
ABSTRACT:
A naturally occurring protein isolated from the saliva of the medicinal leechHirudo medicinalisis described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from aH. medicinaliscDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
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Barnes CS et al., “Production and characterization of saratin, an inhibitor of von Willebrand factor-dependent platelet adhesion to collagen,” Seminars in Thrombosis and Hemostasis, vol. 27, No. 4, pp. 337-348, Aug. 2001.
Fotev Zisi
Güssow Detlef
Hemberger Jürgen
Hofmann Uwe
Scheuble Bernhard
Merck Patent GmbH
Miller, White, Zelano & Branigan, P.C.
Wax Robert A.
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