Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-11-08
2005-11-08
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252300, C435S254110, C435S320100, C435S325000, C536S023500
Reexamination Certificate
active
06962801
ABSTRACT:
A naturally occurring protein isolated from the saliva of the medicinal leechHirudo medicinalisis described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from aH. medicinaliscDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to hard disease and diseases of the circulation system. Furthermore the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
REFERENCES:
patent: 5246715 (1993-09-01), Orevi et al.
patent: 5523287 (1996-06-01), Friedrich et al.
patent: 5705355 (1998-01-01), Tolstoshev et al.
patent: 6881722 (2005-04-01), Barnes et al.
Fotev Zisi
Güssow Detlef
Hemberger Jürgen
Hofmann Uwe
Scheuble Bernhard
Merck Patent GmbH
Millen White Zelano & Branigan P.C.
Wax Robert A.
LandOfFree
Protein for blocking platelet adhesion does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein for blocking platelet adhesion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein for blocking platelet adhesion will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3471291