Protein, DNA coding for same and method of producing the protein

Details Protein, DNA coding for same and method of producing the protein Protein, DNA coding for same and method of producing the protein

1996-07-24

1998-03-24

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 692, 4352523, 4352402, 4353201, 530395, 536 235, C12N 1512, C12N 1570, C12N 1585, C07K 1481

Patent

active

057314128

ABSTRACT:
A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.

REFERENCES:
patent: 5466593 (1995-11-01), Shimomura et al.
Naldini et al. (1992) EMBO J 11:4825-4833 "Extracellular Proteolytic Cleavage by Urokinase is Required for Activation of Hepatocyte Growth Factor . . . ".
Ponte et al. (1988) Nature 331:525-527 "A New A4 Amyloid mRNA Contains a Domain Homologous to Serine Proteinase Inhibitors".
Shimomura et al. (1995) Eur J Biochem 229:257-261 "Activation of Hepatocyte Growth Factor by Two Homologous Proteases, Blood Coagulation Factor XIIa . . . ".
Hillier et al. (1995) Unpublished Database Entries R74593, H94519, W94849, N57450 "The Wash U-Merck EST Project".

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