Protein, DNA coding for same and method of producing the protein

Details Protein, DNA coding for same and method of producing the protein Protein, DNA coding for same and method of producing the protein

1997-11-19

1998-12-29

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435691, 4352523, 4353201, 536 237, 935 11, 935 32, 935 70, C07K 100, C12N 1515, C12N 1579

Patent

active

058543961

ABSTRACT:
A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.

REFERENCES:
patent: 5466593 (1995-11-01), Shimomura et al.
patent: 5731412 (1998-03-01), Shimomura et al.
Neldini et al., EMBO J., 11:4825-4833 (1992).
Ponte et al, Nature, 331;525-527 (1988).
Shimomura et al, Eur. J. Biochem, 229:257-261 (1995).
Hillier et al, "The WashU-Merck EST Project", Accession No. R74593 (Seq. Ref. No. HS593137) (1995).
Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. H94519 (1995).
Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. W94849 (1995).
Hillier et al, "The WashU-Merck EST Project", Unpublished Data Entry No. N57450 (1995).
Hillier et al, "The WashU-Merck EST Project", Accession No. R35464 (Seq. Ref. No. HS46499) (1995).
Hillier et al, "The WashU-Merck EST Project", Accession No. H39798 (Seq. Ref. No. HS798277) (1996).
Miyazawa et al, Journal of Biological Chemistry, 268(14):10024-10028 (1993).
Miyazawa et al, Journal of Biological Chemistry, 271(7):3615-3618 (1996).

Affiliated with

Also associated with

Rating

Protein, DNA coding for same and method of producing the protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein, DNA coding for same and method of producing the protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein, DNA coding for same and method of producing the protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1425885