Protein disulfide isomerase and ABC transporter homologous...

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases

Reexamination Certificate

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C435S193000, C530S350000

Reexamination Certificate

active

07404952

ABSTRACT:
The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.

REFERENCES:
patent: 6060601 (2000-05-01), Langhals et al.
patent: 6753314 (2004-06-01), Giot et al.
patent: 2005/0202421 (2005-09-01), Hirsch et al.
patent: 00/05368 (2000-02-01), None
Croop et al., PIR 80 Database, Accession No. G2068, Dec. 21, 1996.

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