Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1996-08-02
1999-12-21
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424487, 424 7817, 424 7818, 424 7824, A61K 910, A61K 3174, A61K 3178, A61K 3179
Patent
active
060045833
ABSTRACT:
A therapeutic-containing composition adapted for the oral administration of a biologically active material which comprises a water insoluble but water swellable polymer chemically modified with an enzyme inhibitor containing a chemical functionality which has an interactive affinity for target receptors located on the transport barrier walls of the digestive tract of the intended recipient, and at least one therapeutic of low oral bioavailability.
REFERENCES:
patent: 3959080 (1976-05-01), Orth et al.
patent: 4178361 (1979-12-01), Cohen et al.
patent: 4714768 (1987-12-01), Hewklen et al.
patent: 4795436 (1989-01-01), Robinson
patent: 4849227 (1989-07-01), Cho
patent: 5049545 (1991-09-01), Lobermann et al.
patent: 5359030 (1994-10-01), Ekwuribe
patent: 5438040 (1995-08-01), Ekwuribe
patent: 5563056 (1996-10-01), Swan et al.
"Polymers for Colon-Specific Drug Delivery", Kopecek et al., Journal of Controlled Release Mar. 19, 1992, Nos. 1/3, Amsterdam, NL, p. 121-130.
"Immobilization of Ovomucoid on Dextrans", Valuev et al., Polymer Science vol. 34 (1992) No. 11, Birmingham, AL.
"Interaction of Polymeric Derivarives of Trypsin with its Portein Inhibitor", Valuev et al., Polymer Science vol. 37 (Sep.1995) , No. 9, Birmingham, AL.
"Hypoglycemic Effect of Novel Oral Microspheres of Insulin with Protease Inhibitor in Normal and Diabetic Rats", Morishita et al, International Journal of Pharmaceutics, 78(1992)9-16.
"Monosubstituted 2,2-Dimethyl-3-Formyl-L-Thiazolidine-4-Carbonyl Insulins", Lindsay et al, Eur. J. Biobhem. 15 (1970) p. 547.
"Evidence that Insulin Activates an Instrinic Plasma Membrane Protease in Generating a Secondary Chemical Mediator", Seales et al, The Journal of Biological Chemistry, vol. 255, No. 14, Issue of Jul. 25, pp. 6529-6531, 1980.
"Polymer Matrices for Oral Delivery", Greenley et al, Polymer Preprints, 1990, v. 31, N2, pp. 182-183.
"Biodegradable Azopolymer Coating for Oral Delivery of Peptide Drugs", Saffran et al, Biochemical Society Transactions 18(5) 752-4 (1990), pp. 752-754.
Thermally Reversible Hydrogels Containing Biologically Active Species, M. Durrani, Polymers in Medicine III, Elsevier Science Publishers B.V., Amsterdam, 1988, pp. 161-167.
"The Acetylation of Insulin", Lindsay et al, Biochem. J. 121 (1971), p. 737.
"Tryptase from Rat Skin: Purification and Properties", Braganza et al, Biochemistry, vol. 30, No. 20 (1991), pp. 4997-5007.
"Intramolecular Cross-Linked Insulin", D.G. Lindsay, Mar. 1971.
"Improvement of Large Intestinal Absorption of Insulin by Chemical Modification with Palmitic Acid in Rats", Hashizume et al, J. Pharm. Pharmacol. 1992, 44: 557-558.
"Trials of Lipid Modification of Peptide Hormones for Intestinal Delivery", Muranishi et al, Journal of Controlled Release, 19 (1992), pp. 179-180.
"Hypoglycemic Effect of Intestinally Administered Monosaccharide-Modified Insulin Derivatives in Rats", Haga et al, Chem. Pharm. Bull. 39(7) 1983-1986(1990), p. 1983 & p. 1986.
"Effect of Trypsin Inhibitor on Passage of Insulin Across the Intestinal Barrier", Science, 127, 1988, pp. 1115-116.
Ametov Alexander S.
Henis Jay M.S.
Knyazhev Vladimir A.
Plate Nikolai A.
Staroseltseva Ludmila K.
Orex Pharmaceutical Development Corp.
Shust Nestor W.
Webman Edward J.
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