Protein conjugate containing metal radionuclide labeled proteins

Details Protein conjugate containing metal radionuclide labeled proteins Protein conjugate containing metal radionuclide labeled proteins

1996-07-12

1998-05-26

Higel, Floyd D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530402, 560145, 424 11, 424 9, C07K 1600, C12P 2108

Patent

active

057566852

ABSTRACT:
Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.

REFERENCES:
patent: 4233284 (1980-11-01), Fawzi
patent: 4421735 (1983-12-01), Haber et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4673562 (1987-06-01), Davison et al.
patent: 4775745 (1988-10-01), Ford et al.
patent: 4833251 (1989-05-01), Musso et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4895955 (1990-01-01), Ford et al.
patent: 4898951 (1990-02-01), Symons
patent: 4963682 (1990-10-01), Bodor
patent: 4963688 (1990-10-01), Bodor
patent: 5175343 (1992-12-01), Fritzberg et al.
patent: 5242679 (1993-09-01), Fritzberg et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5556982 (1996-09-01), Fritzberg et al.
Davison et al., Inorganic Chem., vol. 20, No. 6, Jun. 1981, "A new class of oxotechnetium (5+) chelate complexes containing a TcOn.sub.2 S.sub.2 core".
Fritzberg, J. Nucl. Med. Tech., vol. 12, No. 4, Dec. 1984, pp. 177-188, "Current status of renal radiopharmaceuticals".
Fritzberg et al., Amer. Chem. Soc. Abstracts, Abstract No. 70, (1984), "Labeling of proteins by chelate conjugation with Tc-99m and Re-188".
Kasina et al., J. Nucl. Med., vol. 29, pp. 1933-40, (1986) "Tissue distribution properties of technetium-99m-diamide dimercaptide complexes and potential use as renal radiopharmaceuticals".
Kasina et al., Sixth International Symp. on Radiopharmaceutical Chem., Boston, Jul. 1986, paper 118 "Application of diamide dimercaptide N.sub.2 S.sub.2 bifunctional chelating agents for 99mTc-labeling of proteins".
Fritzberg, Nuklearmedizin, vol. 26, pp. 7-12 1987, "Advances in .sup.99m Tc-labeling of antibodies".
Fritzberg et al., J. Nucl. Med., vol. 23, pp. 592-598, 1982, "Synthesis and biological evaluation of Tc-99m N,N-Bis (mercaptoacetyl)-2,3-diamino-propanoate: A potential replacement for
Greene, T.W., "Protective Groups in Organic Synthesis," John Wiley and Sons, New York, New York, pp. 206-207 (1981).
Schneider et al., J. Nucl. Med., vol. 25, pp. 223-229 (1984), "N, N'-bis-S-Benoylmercaptoacetamido ethylenediamine and propylenediamine ligands as renal function imaging agents. I. Alternate synthetic methods".
Costello et al., J. Nucl. Med., vol. 24, pp. 353-355, 1983, "The investigation of radiopharmaceutical components by fast atom bomardment mass spectrometry = The identification of Tc-Hida and the epimers of Tc-Co.sub.2 Dads".
Liang et al., J. Nucl. Med., vol. 27, No. 6, p. 1051, Abstract No. 720, (Jun. labeled diaminodithiol for protein labeling (1983).
Paganelli et al., "Intraperitoneal Radio-Localization of Tumors Pre-targeted by Biotinylated Monoclonal Antibodies," Int. J. Cancer vol. 45, pp. 1184-1189, 1990.
Paganelli et al., "Monoclonal antibody pretargeting techniques for tumour localization: the avidin-biotin system," Nucl. Med Communications, vol. 12, pp. 211-234, 1991.
Goodwin/Hnatowich, Letter to the Editor/Reply, J. Nucl. Med., vol. 32, No. 4 pp. 750-751, 1991. Biochem. J., vol. 89, p. 585, 1963.
Kalofonos et al., "Imaging of Tumor in Patients with Indium-III-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communication," J. Nucl. Med., vol. 31, No. 11, pp. 1791-1796, 1990.
Hnatowich et al., "Investigations of Avidin and biotin for Imaging Applications," J. Nucl. Med., vol. 28, No. 8, pp. 1294-1302, 1987.
Rosebrough, Abstract No. 235, J. Nucl. Med., p. 800, 1992, "Plasma stability and Pharmacokinetics of Radio-labeled Deferozamine-Biotin Derivatives".
Virzi et al., Abstract No. 403, J. Nucl. Med., p. 920, 1992, "The preparation and Evaluation of 12 Biotin Derivatives labeled with Tc-99m".
Rosario et al., Abstract No. 356, J. Nucl. Med., vol. 32, No.5, p. 993, 1991, Bolton-Hunter and Biotin derivatized polylysine: A new multi-valent peptide reagent for in vivo pre-targeting with streptavidin conjugates.

Affiliated with

Also associated with

Rating

Protein conjugate containing metal radionuclide labeled proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein conjugate containing metal radionuclide labeled proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein conjugate containing metal radionuclide labeled proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1961802