Protein complexes having Factor VIII:C activity and production t

Details Protein complexes having Factor VIII:C activity and production t Protein complexes having Factor VIII:C activity and production t

1993-12-03

1997-01-21

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4353201, 530383, 536 235, 536 242, C07K 14755, C12N 510, C12N 1512, C12N 1579

Patent

active

055958869

ABSTRACT:
DNA constructs encoding human Factor VIII:C protein are disclosed. In particular, the DNA construct contains a nucleotide sequence that encodes a first polypeptide homologous to the A domain of human Factor VIII:C linked to a second polypeptide homologous to the C domain of human Factor VIII:C by a polypeptide spacer that comprises a peptide homologous to a human Ig heavy chain hinge region. Recombinant methods for producing human Factor VIII:C protein are also disclosed.

REFERENCES:
patent: 4868112 (1989-09-01), Toole et al.
patent: 5084390 (1992-01-01), Hallewell
patent: 5149637 (1992-09-01), Scandell et al.
patent: 5171844 (1992-12-01), van Ooyen et al.
patent: 5198349 (1993-03-01), Kaufman
Toole, et al., A large region (.apprxeq.95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity, (1986) Proc. Natl. Acad. Sci., USA, 83:5939-5942.

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