Protein compatible methods and compounds for controlling the...

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C528S039000, C528S034000

Reexamination Certificate

active

10814123

ABSTRACT:
Siliceous materials were prepared by adding one or more additives, including one or more water soluble polymers, and derivatives thereof, as well as trifunctional silanes, to sols containing tetraalkoxysilanes derived from polyols. The polymers facilitate phase separation of the growing silica gel matrix, leading to high surface area self-supporting silica gels with cure occurring at ambient temperatures. The materials also show a significant reduction in shrinkage properties and significant protein stabilization abilities.

REFERENCES:
patent: 3189662 (1965-06-01), Vaughn
patent: 3374103 (1968-03-01), Barkin
patent: 3997501 (1976-12-01), McLeod
patent: 4588624 (1986-05-01), Nygren et al.
patent: 4673584 (1987-06-01), Nygren et al.
patent: 5009688 (1991-04-01), Nakanishi
patent: 5071674 (1991-12-01), Nogues et al.
patent: 5074916 (1991-12-01), Hench et al.
patent: 5100841 (1992-03-01), Wada et al.
patent: 5243769 (1993-09-01), Wang et al.
patent: 5300564 (1994-04-01), Avnir et al.
patent: 5624875 (1997-04-01), Nakanishi et al.
patent: 5637507 (1997-06-01), Wicks et al.
patent: 5728457 (1998-03-01), Frechet et al.
patent: 6048546 (2000-04-01), Sasaki et al.
patent: 6080402 (2000-06-01), Reetz et al.
patent: 6090448 (2000-07-01), Wallace et al.
patent: 6171986 (2001-01-01), Zhong et al.
patent: 6207098 (2001-03-01), Nakanishi et al.
patent: 6210570 (2001-04-01), Holloway
patent: 6303290 (2001-10-01), Liu et al.
patent: 6531060 (2003-03-01), Nakanishi et al.
patent: 2001/0041459 (2001-11-01), Smith et al.
patent: 2004/0034203 (2004-02-01), Brook et al.
patent: 327722 (1958-03-01), None
patent: 1136114 (1960-07-01), None
patent: 0363697 (1990-04-01), None
patent: 07102216 (1995-04-01), None
patent: WO 98/29350 (1998-07-01), None
patent: WO 01/01139 (2001-01-01), None
patent: WO 01/58562 (2001-08-01), None
Gill et al. Chem. Mater. (2001), 13, pp. 3404-3421.
Gill et al., J. Am. Chem. Soc., (1998), 120, pp. 8587-8598.
Cabrera, K. et al., “SilicaROD™—A new challenge in fast high-performance liquid chromatography separations”, Trends in Analytical Chemistry, 1998, pp. 50-53, vol. 17, No. 1.
Tanaka, N. et al., “Monolithic Silica Columns for HPLC, Micro-HPLC, and CEC”, J. High Resol. Chromatogr., 2000, pp. 111-116, vol. 23, No. 1.
Ishizuka, N. et al., “Preparation and Chromatographic Application of Macroporous Silicate in a Capillary”, Journal of Sol-Gel Science and Technology, 2000, pp. 371-375, vol. 19.
Motokawa, M. et al., “Monolithic silica columns with various skeleton sizes and through-pore sizes for capillary liquid chromatography”, Journal of Chromatography A, 2002, pp. 53-63, vol. 961.
Ishizuka, N. et al., “Chromatographic characterization of macroporous monolithic silica prepared via sol-gel process”, Colloids and Surfaces—A: Physicochemical and Engineering Aspects, 187-188, 2001, pp. 273-279.
Kang, J. et al., “A silica monolithic column prepared by the sol-gel process for enantiomeric separation by capillary electrochromatography”, Electrophoresis, 2002, pp. 1116-1120, vol. 23.
Kikuta, K. et al., “Synthesis of Transparent Magadiite-Silica Hybrid Monoliths”, Chem. Mater., 2002, pp. 3123-3127, vol. 14.
Leinweber, F. C. et al., “Characterization of Silica-Based Monoliths with Bimodal Pore Size Distribution”, Anal. Chem., 2002, pp. 2470-2477, vol. 74.
Nakanishi, K. et al., “Macropore Morphology Control of Silica Gel by Spinodal Decomposition”, Chemical Processing of Advanced Materials, 1992, pp. 29-41.
Nakanishi, K. et al., “Macropore Structure Design of Sol-Gel Derived Silica by Spinodal Decomposition”, Porous Materials, 1993, pp. 51-60.
Gill, I. et al., “Encapsulation of Biologicals within Silicate, Siloxane, and Hybrid Sol-Gel Polymers: An Efficient and Generic Approach”, J. Am. Chem. Soc., 1998, pp. 8587-8598, vol. 120.
Gill, I., “Bio-doped Nanocomposite Polymers: Sol-Gel Bioencapsulates”, Chem. Mater., 2001, pp. 3404-3421, vol. 13.
Nakanishi, K. et al., “Synthisis of silica gel by polymer-mixed sol-gel method”, Chem. Abstracts, AN. 118:259529, Shinsozai (1992), pp. 44-49, vol. 3, No. 11.
Tanaka, N. et al., “Octadecylsilyated porous silica rod for reversed-phase liquid chromatography”, Chem. Abstracts, AN. 121:92756, Kuromatogurafi (1993), pp. 50-51, vol. 14, No. 5.
Fyre, C.L., “Stable Silicon Heterocyclic Derivatives of Branced Alkanediols”, The Journal of Organic Chemistry, 1969, pp. 2496-2499, vol. 34, No. 9.
Voronkov M.G. et al., Chem. Abst. No. 69:58787, “Spirocyclic orthosilicic acid esters”, Z. Chem., 1968, pp. 252-253, vol. 8, No. 7.
Gainsford, G.J. et al., “Sodium Bis[1,2-ethanediolato(2-)](hydroxy-ethoxo)silicate(1-) Acetonitrile Solvate, Na[Si(C2H4O2)2(C2H5O2)].0.25C2H3N”, Acta Cryst., 1995, pp. 8-10, C51.
Müller, R. et al., Chem. Abst. No. 55:143332, “Silicones. LII. The identification and separation of alkoxy and aryloxy compounds with pentacovalent silicon”, Chem. Berichte, 1961, pp. 1943-1951, vol. 94.
Kemmitt, T. et al., “The Ring Size Influence on29Si N.M.R. Chemical Shifts of Some Spirocyclic Tetra- and Penta -coordinate Diolato Silicates”, Aust. J. Chem., 1995, pp. 93-102, vol. 48.
Arsene, C. et al., “Cyclic Chiral Silyl Derivaties for the Determination of the Absolute Configuration of Aliphatic Diols by Gas Chromatography”, Org. Lett., 2002, pp. 2869-2871, vol. 4, No. 17.
Spindler, R. et al., “Investigations of a Siloxane-Based Polymer Electrolyte Employing13C,29Si,7Li, and23Na Solid-State NMR Spectroscopy”, J. Am. Chem. Soc., 1988, pp. 3036-3043, vol. 110.
Sattler, K. et al., Chem. Abst. No. 134: 195237, “A new glycol precursor for template synthesis and its interaction with a surfactant”, Chemie Ingenieur Technik, 2000, pp. 487-491, vol. 72, No. 5.
Cheng, H. et al., “Neutral Alkoxysilanes from Silica”, J. Am. Chem. Soc., 2000, pp. 10063-10072, vol. 122.
Kinrade S.D. et al., “Stable Five- and Six-Coordinated Silicate Anions in Aqueous Solution”, Science, 1999, pp. 1542-1545, vol. 285.
Kinrade, S.D. et al., “Silicon-29 NMR evidence of alkoxy substituted aqueous silicate anions”, J. Chem. Soc., Dalton Trans., 1999, pp. 3149-3150.
Kinrade, S.D. et al., “Aqueous hypervalent silicon complexes with aliphatic sugar acids”, J. Chem. Soc., Dalton Trans., 2001, pp. 961-963.
Spindler, R. et al., “Synthesis, NMR Characterization, and Electrical Properties of Siloxane-Based Polymer Electrolytes”, Macromolecules, 1998, pp. 648-654, vol. 21.
Schomburg, D., “Strong Distortion of the Tetrahedral Geometry in a Spirosilicate: Molecular Structure of Bis(tetramethylethylenedioxy)silane”, Angew. Chem. Intl. Ed., 1983, p. 65, vol. 22, No. 1.
Moore, J.C., “Gel Permeation Chromatography. I. A New Method for Molecular Weight Distribution of High Polymers”, Journal of Polymer Science Part A, 1964, pp. 835-843, vol. 2.
Mehrotra, R.C. et al., “Reactions of Tetramethoxy- & Triethoxysilanes with Glycols”, Indian J. Chem., 1967, pp. 444-448, vol. 5.
Mehrotra, R.C. et al., “Organic Derivatives of Silicon. Part V. Reactions of Silicon Tetra-acetate with Glycols: Synthesis of Glycol Derivatives of Silicon”, Indian Jour. Chem. Soc., pp. 563-566, vol. 41, No. 8.
Hahn, W., Chem. Abst. No. 49:8249, “Sprio silicates from silicon tetrachloride and diols”, Makromolekulare Chemie, 1953, pp. 51-83, vol. 11.
Voronkov, M.G. et al., “Alkoxysilanes. XXIII. Spirocyclic esters of silicic acids”, Chem. Abst. No. 70:68820.
Kuznetsova, V.P. et al., “Synthesis of hydroxysilanes and urethanes based on them”, Chem. Abst. No. 71:39061.
Kopylov, V.M. et al., “Transesterification of tetraethoxysilane with difunctional alcohols in the presence of nucleophilic catalysts”, Chem. Abst. No. 108:86867.
Dave,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Protein compatible methods and compounds for controlling the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein compatible methods and compounds for controlling the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein compatible methods and compounds for controlling the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3915139

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.