Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-11-26
1999-12-21
Priebe, Scott D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
424428, 427 21, 604 53, 435455, 4353201, 530354, 530356, 623 1, A61K 4800
Patent
active
06004943&
ABSTRACT:
This invention is directed to an article, such as a medical device, for local delivery of genes. The article comprises a substrate coated with a cross-linked protein. The invention is also directed to a method for coating an article with cross-linked protein. An additive may be optionally incorporated into the coating. The crosslinked protein coating can strongly absorb genes. Thus, the coated article can be used to locally deliver genes to a target site. The coating of the invention exhibits excellent biocompatibility and biodegradability, and does not cause toxicity or side-effects.
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Gao Run-lin
Shi Rui-wen
Cardiovascular Inst. of Fu Wai Hospital, Chinese Acdmy of Med. S
Inst. of Biomedical Engineering, Chinese Acdmy of Med. Science
Nguyen Dave Trong
Priebe Scott D.
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