Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-05-28
2010-10-26
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C436S063000
Reexamination Certificate
active
07820376
ABSTRACT:
The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the patient to recover from the inflammatory condition and identifying patients based on their prognosis. The invention also provides for methods of identifying other polymorphisms that correspond with the ability of the patient to recover from the inflammatory condition.
REFERENCES:
Hegele, Arterioscler. Thromb. Vasc. Biol. 2002, vol. 22, pp. 1058-1061.
Hattersley et al. (Lancet, 2005, vol. 366, pp. 1315-1323).
Ionnidis (Plost Med, 2005, 2(8):e124).
Kroese et al. (Genetics in Medicine, vol. 6 (2004), p. 475-480).
Blamey, S.L, et al. Protein c antigen levels in major abdominal surgery: relationships to deep vein thrombosis, malignancy and treatment with stanozolol. Thromb Haemost (1985) 54(3):622-625.
Faust, S.N, et al. Dysfunction of endothelial protein c activation in severe meningococcal sepsis. New Eng J Med (2001) 345(6):408-416.
Fijnvandraat, K., et al. Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein c levels predict a high mortality. Thromb Haemost (1995) 73(1):15-20.
Fisher, C.J. and Yan, S.B. Protein c levels as a prognostic indicator of outcome in sepsis and related diseases. Critical Care Medicine (2000) 28(9 Suppl):S49-S56.
Foster, D.C., et al. The nucleotide sequence of the gene for human protein c. Proc Natl Acad Sci USA (1985) 82(14):4673-4677.
Griffin, J.H., et al. Protein c, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation. Blood (1982) 60(1):261-264.
Hesselvik, J.F., et al. Protein c, protein s and c4b-binding protein in severe infection and septic shock. Thromb Haemost (1991) 65(2):126-129.
Spek, C.A., et al. Two mutations in the promoter region of human protein c gene both cause type I protein c deficiency by disruption of two HNF-3 binding sites. J Biologic Chemistry (1995) 270(41):24216-21.
Taylor, F.B., et al. Protein c prevents the coagulopathic and lethal effects ofEscherichia coliinfusion in the baboon. J Clin Invest (1987) 79:918-925.
Vervloet, M.G., et al. Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock. Semin Thromb Hemost (1998) 24(1):33-44.
Yan, S.B. and Dhainaut, J.F. Activated protein c versus protein c in severe sepsis. Critical Care Medicine (2001) 29(7):S69-S74.
David, M., et al. “Identification of mutations in 15 Hungarian families with hereditary protein C deficiency”, British Journal of Haematology, (2000), 111:129-135.
Espana, Francisco, et al. “Inherited abnormalities in the protein C activation pathway”, Pathophysiology of Haemostatis and Thrombosis, (2002), 32:241-244.
Faioni, Elena, M., et al. “Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity”, British Journal of Haematology, (2000), 108:265-271.
Gandrille, S., et al. “First de novo mutations in the protein C gene of two patients with type I deficiency:” a missense mutation and a splice site deletion, Blood, (1994), 84(8):2566-2570.
Gandrille, S., et al. “Identification of mutations in 90 of 121 consecutive symptomatic French patients with a type I protein C deficiency”, Blood, (1995) 86(7):2598-2605.
Labrouche, Sylvie, et al. “Protein C and protein S assessment in hospital laboratories: which strategy and what role for DNA sequencing?”, Blood Coagulation and Fibrinolysis, (2000), 14:531-538.
Le Cam-Duchez, Veronique, et al. “Influence of three potential genetic risk factors for thrombosis in 43 families carrying the factor V Arg 506 to Gln mutation”, British Journal of Haematology, (1999), 106:889-897.
Millar, David S, et al. “Molecular genetic analysis of severe protein C deficiency”, Hum Genet (2000), 106:646-653.
Naito, Masao, et al. “Defective sorting to secretory vesicles in trans-golgi network is partly responsible for protein C deficiency”, Circ. Res. (2003), 92:865-872.
Reitsma, Pieter H., “Protein C deficiency: summary of the 1995 database update”, Nucleic Acids Research, (1996), 24(1):157-159.
Taylor, F.B., “The endothelial cell protein C receptor aids in host defense againstEscherichia colisepsis”, Blood, (2000), 95(5): 1680-1686.
G. R. Bernard, et al., “Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis,” The New England Journal of Medicine, vol. 344, No. 10, Mar. 8, 2001, pp. 699-709.
C. Arnold Spek, et al., “Genotypic Variation in the Promoter Region of the Protein C Gene is Associated with Plasma Protein C Levels and Thrombotic Risk,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 15, No. 2, Feb. 1995, pp. 214-218.
Martine Aiach, et al., “Complex Association of Protein C Gene Promoter Polymorphism with Circulating Protein C Levels and Thrombotic Risk,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, No. 6, Jun. 1999, pp. 1573-1576.
D. Scopes, et al., “Polymorphic Variation in the Human Protein C (PROC) Gene Promoter Can Influence Transcriptional Efficiency in Vitro,” Blood Coagulation and Fibrinolysis, vol. 6, No. 4, Jun. 1995, pp. 317-321.
Cheryl Holmes, et al., “Genetic Polymorphisms in Sepsis and Septic Shock,” Chest, vol. 124, No. 3, Sep. 2003, pp. 1103-1115.
Roger C. Bone et al., “Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis,” The ACCP/SCCM Consensus Conference Committee: Chest (1992) 101:1644-55.
Ramakant Khazanie, “Elementary Statistics in a World of Applications” 3rd Ed., p. 400-401 Scott, Foresman/Little, Brown Higher Education (publisher), 1990.
Russell James A.
Walley Keith R.
Bausch Sarae
Browdy and Neimark PLLC
University of British Columbia
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