Protein C derivatives

Details Protein C derivatives Protein C derivatives

2005-01-11

2005-01-11

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C514S001000, C514S004300, C514S802000, C514S822000, C424S094640, C530S381000, C530S830000

Reexamination Certificate

active

06841371

ABSTRACT:
Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity and resistance to inactivation by serpins, compared to wild-type protein C and retain the biological activity of the wild-type human protein D. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hyper coagulable states, thrombotic disorders and disease states predisposing to thrombosis.

REFERENCES:
patent: 4992373 (1991-02-01), Bang et al.
patent: 5196322 (1993-03-01), Bang et al.
patent: 5270178 (1993-12-01), Gerlitz et al.
patent: 5358932 (1994-10-01), Foster et al.
patent: 5453373 (1995-09-01), Gerlitz et al.
patent: 5460953 (1995-10-01), Gerlitz et al.
patent: 5837843 (1998-11-01), Smirnov et al.
patent: 5847085 (1998-12-01), Esmon et al.
patent: 6017882 (2000-01-01), Nelsestuen
patent: 0 296 413 (1988-09-01), None
patent: 0 354 504 (1989-05-01), None
patent: 0 443 874 (1991-02-01), None
patent: 03 072877 (1991-03-01), None
patent: WO 9109960 (1991-07-01), None
patent: WO 9844000 (1998-10-01), None
patent: WO 9920767 (1999-04-01), None
patent: WO 0066754 (2000-11-01), None
patent: WO 0136462 (2001-05-01), None
patent: WO 0157193 (2001-08-01), None
patent: WO 0159084 (2001-08-01), None
patent: WO 0172328 (2001-10-01), None
patent: WO 02070681 (2002-09-01), None
U.S. patent application Ser. No. 09/467,591, Nelsestuen, Feb. 3, 2000.
U.S. patent application Ser. No. 09/803,810, Nelsestuen, Mar. 12, 2001.
Database Swall Online!, “Vitamin K-dependent protein C precursor”European Bioinformatics Institute&Swiss Institute for Bioinformatics, 1986.
Grinnell B, et al., “Glycosylation of Human protein C Affects Its Secretion, Processing, Functional Activities, and Activation by Thrombin”,Journal of Biological Chemistry, vol. 226, No. 15, 1991; pp. 9778-9785.
Rezaie AR, et al., “Conversion of Glutamic Acid 192 to Glutamine in Activated Protein C Changes the Substrate Specificity and Increases Reactivity toward Macromolecular Inhibitors*”,Journal of Biological Chemistry, vol. 268, No. 27, 1993, pp. 19943-19948.
Mather T, et al., “The 2.8A crystal structure of Gla-domainless activated protein C”,The Embo Journal, vol. 15, No. 24, 1996, pp. 6822-6831.
Tsiang M, et al., “Protein Engineering Thrombin for Optimal Specificity and Potency of Anticoagulant Activity in Vivo”,Biochemistry, vol. 35, No. 51, 1996, pp. 16449-16457.
Rezaie AR, “Role of Residue 99 at the S2 Subsite of Factor Xa and Activated Protein C in Enzyme Specificity”,Journal of Biological Chemistry, The American Socirty of Biological Chemists, Inc., vol. 271, No. 39, 1996, pp. 23807-23814.
Kurz K, et al., “Antithrombic Efficacy in the Guinea Pig of a Derivative of Human Protein C With Enhanced Activation by Thrombin”,Blood, vol. 89, No. 2, 1997, pp. 534-540.
Shen L, et al., “Enhancing the Activity of Protein C by Mutagenesis To Improve the Membrane-Binding Site: Studies Related to Proline-10”Biochemistry, American Chemical Society, vol. 36, No. 51, 1997, pp. 16025-16031.
Shen L, et al., “Enhancement of Human Protein C Function by Site-directed Mutagenesis of the y-Carboxyglutamic Acid Domain”,Journal of Biological Chemistry, American Society of Biological Chemists, vol. 273, No. 47, 1998, pp. 31086-31091.
McDonald J, et al., “Comparison of Naturally Occuring Vitamin K-Dependent Proteins: Correlation of Amino Acid Sequences and Membrane Binding Properties Suggests a Membrane Contact Site”,Biochemistry, vol. 36, No. 17, 1997, pp. 5120-5127.
Zhang L, et al., “The Contributions of Individual y-Carboxyglutamic Acid Residue in the Calcium-dependent Binding of Recombinant Human Protein C to Acidic Phospholipid Vesicles”,The Journal of Biological Chemistry, vol. 268, No. 16, 1993, pp. 12040-12045.
U.S. patent application Ser. No. 09/719,911, Gerlitz et al.
U.S. patent application Ser. No. 10/129,893, Gerlitz et al.
U.S. patent application Ser. No. 10/182,263, Gerlitz et al.

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