Protein C derivatives

Details Protein C derivatives Protein C derivatives

1993-07-09

1995-09-26

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

424 9464, 435 691, 435212, 43525233, 4353201, 514 2, 536 221, 536 231, 536 232, 536 234, C12N 500, C12N 1500, C12P 2106, C07H 1900

Patent

active

054533732

ABSTRACT:
Human protein C derivatives with high activity and reduced dependence on thrombin activation are described. These derivatives differ from the native forms of human protein C in their increased activation rates, functional activities and carbohydrate structures. DNA compounds, transfer vectors, expression vectors and transformants useful in producing these derivatives are also described.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
patent: 4981952 (1991-01-01), Yan
patent: 4992373 (1991-02-01), Bang et al.
U.S. Patent Application Ser. No. 07/771,880 filed Oct. 4, 1991 by Bang et al.
U.S. Patent Application Ser. No. 07/484,133 filed Feb. 23, 1990 by Gerlitz et al.
U.S. Patent Application Ser No. 07/628,063 filed Dec. 21, 1990 by Gerlitz et al.
Ehrlich, et. al., 1990, EMBO J. 9:2367-2373.
Grinnell, et. al., 1991, J. Biol. Chem. 226:9778-9785.
Grinnell, et. al., in Protein C and Related Anticoagulants (eds. Bruley, D & Drohan, W.) 29-63 (Gulf Publishing Co., Houston, 1990).
Grinnell et. al., 1987, Bio/Technology 5:1189-1192.
LeBonniec, et. al., 1991, Proc. Natl. Acad. Sci. USA 88:7371-7375.
LeBonniec, et. al., 1991, J. Biol. Chem. 266:13796-13803.

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