Protein C activator, methods of preparation and use thereof

Details Protein C activator, methods of preparation and use thereof Protein C activator, methods of preparation and use thereof

1986-05-09

1989-07-18

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 98, 435 23, 435 24, 435 68, 4351721, 530381, A61K 3700

Patent

active

048494038

ABSTRACT:
A method and composition for assaying protein C is described. The method comprises reacting a protein C-containing medium with a protein C-activating activator preparation obtained from venom of the snake Agkistrodon contortrix, or venom of another snake species which undergoes an immunological cross-reaction with the venom of Agkistrodon contortrix, to cause maximum activation of protein C and subsequently determining the quantity of activated protein C, said quantity being proportional to the amount of protein C in said medium. Also disclosed is a method and composition for treating thrombotic disorders with the activator preparation and a method of obtaining the activator preparation by culturing of a cloned microorganism.

REFERENCES:
Exner et al.-Chem. Abst., vol. 104 (1986) p. 47533g.
Stocker et al.-Chem. Abst., vol. 105 (1986) p. 74085q.
Moran et al.-Comp. Biochem. Physiol. B, vol. 70B (2)(1981)pp. 349-351.
Moran et al.-Chem. Abst., vol. 96 (1982) p. 64662q.

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