Protein C activator

Details Protein C activator Protein C activator

1987-07-02

1990-03-13

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435184, 435 13, 435212, 435810, 424 9464, C12N 950, C12N 948, C12Q 156

Patent

active

049083147

ABSTRACT:
A protein C activator is purified from the venom of the Southern copperhead snake. The resultant enzyme is a very specific and efficient activator of protein C. The high efficiency and specificity enables the sensitive measurement of functional protein C levels in plasma and other biological fluids. The enzyme is attached to a solid support material and the resultant enzyme reactor is capable of producing activated protein C at a high yield and is stable under the conditions of use.

REFERENCES:
Kisiel et al., Biochem. Biophys. Res. Commun., 143(3): 917-922, Mar. 30, 1987.
Kisiel et al., Biochem., 16(26): 5824-5831 (1977).
Brandt, Clinics in Laboratory Medicine, vol. 4, No. 2, W. B. Saunders Company, Philadelphia, Pa., 247-249 (1984).
Kisiel et al., J. Biol. Chem., 262(26): 12607-12613, Sep. 15, 1987.
Martinoli et al., Thrombosis Research 43:253-264, 1986.
Klein et al., Biochemistry 25:4175-4179, 1986.
Stocker et al., Behring. Inst. Mitt. 79:37-47, 1986.

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