Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-05-13
2000-09-26
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435212, 530412, G01N 33573
Patent
active
061241083
ABSTRACT:
This invention relates to the discovery that toxicity to mustard may be euated by diagnostic test means disclosed herein. Upon electrophoretic separation (sodium dodocyl sulfate polyacryl-amide gel electrophoresis (SDS-PAGE)) of buffered extract of human skin cells (normal human epidermal keratinocytes (NHEK)) which had been exposed to mustard-type chemical compounds a band at approximately 50,000 to 80,000 daltons molecular weight was found. The protein band constitutes a biomarker. The marker protein can be used either to raise protective antibodies to protect against the protease or may be used in a kit for identifying presence or absence of the marker in study of tissues taken from individuals who may have been exposed to mustard poisoning.
REFERENCES:
patent: 4343734 (1982-08-01), Lian et al.
Harris Charles H.
Housel James C.
Moran John Francis
Phan Quang N
The United States of America as represented by the Secretary of
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