Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2008-01-01
2008-01-01
Bragdon, Kathleen Kerr (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S069100, C435S252300, C435S320100, C536S023200
Reexamination Certificate
active
10469486
ABSTRACT:
An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 1; (b) a protein comprising a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having protease activity.
REFERENCES:
patent: 5399283 (1995-03-01), Stabinsky et al.
patent: 6406900 (2002-06-01), Hunter et al.
Mazumdar-Geighton, S. et al., Identification of novel serine proteinase gene transcripts in the midgets of two tropical insect pest,Scirpophaga incertulas(Wk.) andHelicoverpa armigera(Hb.), Insect Biochemistry and Molecular Biology, 2000, vol. 30, No. 1, pp. 57 to 68.
Lehane, S.M. et al., Cloning, sequencing, temporal expression and tissue-specificity of two serine proteases from the midgut of the blood-feeding flyStomoxys calcitrans., Eur.J.Biochem., 1998, vol. 254, No. 2, pp. 290 to 296.
Kotani, E. et al., Cloning and sequence of a cDNA for a highly basic protease from the digestive juice of the silkworm, Bombyx mori., Insect Mol Biol, 1999, vol. 8, No. 2, pp. 299 to 304.
Jiang, H. et al., Four serine proteinases expressed in Manduca sexta haemocytes, Insect Mol Biol, 1999, vol. 8, No. 1, pp. 39 to 53.
Adams, M.D., et al. “The Genome Sequence ofDrosophila melanogaster” American Association for the Advancement of Science(2000) vol. 287, pp. 2185-2195 XP-000961051.
Database Uniprot. Adams, M.D., et al. “The genome sequence ofDrosophila melanogaster” EBI(2000) XP-002288320.
Nakamori Shigeru
Takagi Hiroshi
Takahashi Masakazu
Tsujimoto Kazuhisa
Yamada Hideyuki
Bragdon Kathleen Kerr
Ladas and Parry LLP
Moore William W.
Seiren Kabushiki Kaisha
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