Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2006-11-29
2011-11-15
Nashed, Nashaat (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C435S155000
Reexamination Certificate
active
08058037
ABSTRACT:
The present invention provides a protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for proteins of the amino acid sequences as shown in SEQ ID NOS: 4 to 6), and a process for industrially advantageously producing a compound that inhibits HMG-CoA reductase and has an action to decrease serum cholesterol, using DNA encoding the protein comprising the amino acid sequence as shown in any one of SEQ ID NOS: 1 to 3 (except for DNA encoding the protein comprising the amino acid sequence as shown in SEQ ID NO: 4).
REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4410629 (1983-10-01), Terahara et al.
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4686191 (1987-08-01), Itoh et al.
patent: 5160735 (1992-11-01), Yasumura et al.
patent: 5218092 (1993-06-01), Sasaki et al.
patent: 5342775 (1994-08-01), Yasumura et al.
patent: 6043064 (2000-03-01), Davis et al.
patent: 6245535 (2001-06-01), Takano et al.
patent: 6468780 (2002-10-01), Takano et al.
patent: 6893848 (2005-05-01), Yokoi et al.
patent: 6946270 (2005-09-01), Hashimoto et al.
patent: 7049111 (2006-05-01), Endo et al.
patent: 7186532 (2007-03-01), Ikeda et al.
patent: 7470528 (2008-12-01), Endo et al.
patent: 2006/0154348 (2006-07-01), Endo et al.
patent: 2006/0234337 (2006-10-01), Arisawa et al.
patent: 2008/0261273 (2008-10-01), Endo et al.
patent: 0 243 153 (1987-10-01), None
patent: 0 263 716 (1988-04-01), None
patent: 1 148 122 (2001-10-01), None
patent: 57-50894 (1982-03-01), None
patent: 58-110600 (1983-07-01), None
patent: 63-299 (1988-01-01), None
patent: 63-233798 (1988-09-01), None
patent: 63-248394 (1988-10-01), None
patent: 2-227075 (1990-09-01), None
patent: 2-257891 (1990-10-01), None
patent: 3-22979 (1991-01-01), None
patent: 7-184670 (1995-07-01), None
patent: 96/40863 (1996-12-01), None
patent: 99/07872 (1999-02-01), None
patent: 00/43533 (2000-07-01), None
patent: 00/44886 (2000-08-01), None
patent: 00/63388 (2000-10-01), None
patent: 02/099109 (2002-12-01), None
patent: 03/087381 (2003-10-01), None
Kunst et al., “The complete genome sequence of the Gram-positive bacteriumBacillus subtilis” Nature, vol. 390, pp. 249-256 (1997).
Hashimoto et al., “Search for a bacteria having compactin hydroxylating activity,”Japan Society for Bioscience, Biotechnology, and Agrochemistry2A11a11 (2004), along with an English language abstract thereof.
Yonetani et al., “Cloning a gene encoding compactin hydroxylating enzyme,”Japan Society for Bioscience, Biotechnology, and Agrochemistry2A11a12 (2004), along with an English language abstract thereof.
Endo et al., ML-236A, ML-236B, and ML-236C, New Inhibitors of Cholesterogenesis Produced byPenicillium citrinum, The Journal of Antibiotics, vol. 29, pp. 1346-1348 (1976).
English language Abstract of JP 57-50894.
English language Abstract of JP 7-184670.
Okayama et al., “A cDNA Cloning Vector That Permits Expression of cDNA Inserts in Mammalian Cells”Mol. Cell. Biol., vol. 3, No. 2, pp. 280-289 (1983).
Gerhus et al., “Paracoccus denitrificansCytochromec1Gene Replacement Mutants”J. Bacteriol., vol. 172, No. 5, pp. 2392-2400 (1990).
English Language abstract of JP 58-110600.
Sekine et al., “Cloning and expression of cDNA for salmon growth hormone inEscherichia coli” Proc. Natl. Acad. Sci. USA, vol. 82, pp. 4306-4310 (1985).
English Language abstract of JP 63-233798.
Cohen et al., “Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation ofEscherichia coliby R-Factor DNA”Proc. Nat. Acad. Sci. USA, vol. 69, No. 8, pp. 2110-2114 (1972).
English Language abstract of JP 63-248394.
Hinnen et al., “Transformation of yeast”Proc. Natl. Acad. Sci. USA, vol. 75, No. 4, pp. 1929-1933 (1978).
Ito et al., “Transformation of Intact Yeast Cells Treated with Alkali Cations”J. Bacteriol., vol. 153, No. 1, pp. 163-168 (1983).
English Language abstract of JP 3-22979.
English Language abstract of JP 2-227075.
Feigner et al., “Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure”Proc. Natl. Acad. Sci. USA, vol. 84, pp. 7413-7417 (1987).
English Language abstract of JP 2-257891.
Koizumi et al., “Production of riboflavin by metabolically engineeredCorynebacterium ammoniagenes” Appl. Microbiol. Biotechnol., vol. 53, pp. 674-679 (2000).
U.S. Appl. No. 12/272,448 to Endo et al., entitled “Process for Producing HMG-CoA Reductase Inhibitor,” filed on Nov. 17, 2008.
Database UniProt May 30, 2000 (May 3, 2000). Rivolta, C. et al.: “A 35.7 kb DNA fragment fromB. subtilischromosome containing a putative 12.3 kb operon involved in hexuronate catabolism and a perfect catabolite-responsive element” XP002515180 retrieved from IBIS Database accession No. YJIB—BACSU O34374.
Hashimoto Shin'ichi
Maeda Masaki
Yonetani Yoshiyuki
Greenblum & Bernstein PLC
Kyowa Hakko Bio Co. Ltd.
Nashed Nashaat
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