Protein AMSH and cDNA thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S069100, C435S320100

Reexamination Certificate

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06838551

ABSTRACT:
This application provides a human protein AMSH having the amino acid sequence of SE ID No. 1 which is a novel signal transduction molecule interacting with the SH3 domain of cytokine based signal transduction molecule STAM; a gene encoding the above AMSH; a cDNA having the nucleotide sequence of SEQ ID No. 2; and antibody against AMSH.

REFERENCES:
patent: 6673570 (2004-01-01), Itoh et al.
patent: 20020156012 (2002-10-01), Lyapina et al.
patent: 20030166243 (2003-09-01), Cope et al.
NCBI Accession No. BAB31909, Feb. 8, 2001.*
Kazuo Sugamura et al., “Possible involvement of a novel STAM-associated molecule “AMSH” in intracellular signal transduction mediated by cytokines”, J. Biol. Chem., vol. 274, No. 27, pp. 19129-19135, Jul. 1999.
Wei Yu et al., “Large-scale concatenation cDNA sequencing”, Genome Research, vol. 7, No. 4, pp. 353-358, 1997.
Meredith A. Wentland et al., “A “double adaptor” method for improved shotgun library construction”, Analytical Biochemistry, vol. 236, No. 1, pp. 107-113, 1996.
K. Sugamura et al., “STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction”, Immunity, vol. 6, No. 4, pp. 449-457, 1997.

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