Protein affecting K.sub.ATP channels

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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530326, 530402, 530412, 530418, 530419, 530427, C07K 1400

Patent

active

059257423

ABSTRACT:
This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.

REFERENCES:
patent: Re31244 (1983-05-01), Petersen
patent: 4057636 (1977-11-01), Petersen
H. J. Petersen, et al., "Synthesis and Hypotensive Activity of N-Alkyl-N"-Cyano-N'-Pyridylguanidines", J. Med. Chem., 21, 8, pp. 773-781 (1978).

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