Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1997-08-26
1999-07-20
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530326, 530402, 530412, 530418, 530419, 530427, C07K 1400
Patent
active
059257423
ABSTRACT:
This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.
REFERENCES:
patent: Re31244 (1983-05-01), Petersen
patent: 4057636 (1977-11-01), Petersen
H. J. Petersen, et al., "Synthesis and Hypotensive Activity of N-Alkyl-N"-Cyano-N'-Pyridylguanidines", J. Med. Chem., 21, 8, pp. 773-781 (1978).
Deibel, Jr. Martin R.
Groppi, Jr. Vincent E.
Wolfe Mark L.
Yem Anthony W.
Mohamed Abdel A.
Pharmacia & Upjohn Company
Tsang Cecilia J.
Wootton Thomas A.
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