Protein affecting K.sub.ATP channels

Details Protein affecting K.sub.ATP channels Protein affecting K.sub.ATP channels

1994-11-17

1999-01-05

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

530326, 435 701, 435 703, 4352402, 514 13, 514 21, C07K 100, C12P 2100, A61K 3800

Patent

active

058564497

ABSTRACT:
This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.

REFERENCES:
patent: Re31244 (1983-05-01), Petersen
patent: 4057636 (1977-11-01), Petersen
patent: 5356775 (1994-10-01), Hebert et al.
Hopkins et al, The Journal of Biological Chemistry, vol. 251, No. 14, pp. 4365-4371, Jul. 25, 1976.
Braughler et al, Biochemica et Biophysica Acta, vol. 481, pp. 313-327, 1977.
Molla et al, Biochemistry, vol. 25, pp. 3415-3424, 1986.
Dolci et al, Int. J. Cancer, vol. 54, pp. 302-308, 1993.
Richarme et al, The Journal of Biological Chemistry, vol. 268, No. 13, pp. 9473-9477, May 5, 1993.
H. J. Petersen, et al., "Synthesis and Hypotensive Activity of N-Alkyl-N"-Cyano-N'-Pyridylguanidines", J. Med. Chem., 21, 8, pp. 773-781 (1978).

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