Protein A perfusion and post perfusion drug infusion

Details Protein A perfusion and post perfusion drug infusion Protein A perfusion and post perfusion drug infusion

1990-08-06

1992-02-25

Spear, Frank

Liquid purification or separation

Processes

Treating by enzyme

210638, 210653, 210266, 21050029, B01D 6902

Patent

active

050910914

ABSTRACT:
Disclosed is extracorporeal plasma perfusion over a therapeutic immobilized protein A (staphylococcal), SPA. The perfused plasma is returned to the host or can be taken off one person and used to treat another and stored in perfused plasma banks. Immobilized protein A quantities, volumes of plasma perfused and the rate of administration based on clinical and toxicity evaluations are set forth. A non-toxic drug infusion during the immediate postperfusion period obtains an observed tumoricidal response far exceeding those due to the extracorporeal plasma perfusion or drug infusion alone representing an in vivo synergism between the perfused plasma and the drug. Also disclosed are the therapeutic protein A cartridge, its loading and delivery system, and a miniaturized immunoabsorbent apparatus enabling the processing of serum samples for testing small quantities of plasma.

REFERENCES:
patent: 4243532 (1981-01-01), Tsuda et al.
Bansal et al., "Ex Vivo Removal of Serum IgG in a Patient with Colon Carcinoma, Some Biochemical, Immunological and Histological Observations", Cancer, 42, 7/1978.

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