Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-03-27
1992-01-28
Kepplinger, Esther L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 530403, 530408, 530825, 530413, 530350, 530395, 435 691, 435 697, 4351722, 4351723, 4352402, 935 11, 436828, C07K 1504
Patent
active
050845594
ABSTRACT:
The subject invention concerns novel protein A or protein A-like molecules that can be coupled to other materials through a single, defined site on the protein A molecule. Specifically exemplified is Cysteinyl-rProtein A.TM.. The compounds of the invention, for example, Cysteinyl-rProtein A.TM., can be used in processes wherein protein A is used.
REFERENCES:
patent: 4430318 (1984-02-01), Langone
patent: 4479940 (1984-10-01), Bizzini et al.
patent: 4592995 (1986-06-01), Hayano et al.
patent: 4705845 (1987-11-01), Cerami et al.
patent: 4716122 (1987-12-01), Scheeferse
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4894443 (1990-01-01), Greenfield et al.
Lofdahl, S. et al. (1983), "Gene for Staphylococcal Protein A", Proc. Natl. Acad. Sci. U.S,.A. 80:697-701.
Colbert, D. et al. (1984), "Molecular Organization of the Protein A Gene and Its Expression in Recombinant Host Organisms", Jour. of Biol. Response Modifiers 3:255-259.
Langone, J. J. (1982), "Applications of Immobilized Protein A in Immunochemical Techniques", J. Immunol. Methods 55:277-296.
Fersht, A. R., and A. J. Wilkinson (1985), "Fine Structure-Activity Analysis of Mutations at Position 51 of Tyrosyl-tRNA Synthetase", Biochemistry 24:5858-5861.
Matheson, N. R., H. L. Gibson, R. A. Hallewell, P. J. Barr, and J. Travis (1986), "Recombinant DNA-Derived Forms of Human Alpha.sub.1 -Proteinase Inhibitor", The Journal of Biological Chemistry 261(22):10404-10409.
Sauer, R. T., K. Hehir, R. S. Stearman, M. A. Weiss, A. Jeitler-Nilsson, E. G. Suchanek, and C. O. Pabo (1986), "An Engineered Intersubunit Disulfide Enhances the Stability and DNA Binding of the N-Terminal Domain of Lambda Repressor", Biochemistry 25:5992-5998.
Perry, L. J. and R. Wetzel (1986), "Unpaired Cysteine-54 Interferes with the Ability of an Engineered Disulfide to Stabilize T4 Lysozyme", Biochemistry 25:733-739.
Hurle, M. R., N. B. Tweedy, and C. R. Matthews (1986), "Synergism in Folding of a Double Mutant of the Alpha Subunit or Tryptophan Synthase", Biochemistry 25:6356-6360.
Wells, J. A., and D. B. Powers (1986), "In Vivo Formation and Stability of Engineered Disulfide Bonds in Subtilisin", The Journal of Biological Chemistry 261(14):6564-6570.
Sigal, I.S., B. G. Harwood, and R. Arentzen (1982), "Thiol-Beta-Lactamase: Replacement of the Active-Site Serine of RTEM Beta-Lactamase by a Cysteine Residue", Proc. Natl. Acad. Sci. U.S.A. 79:7157-7160.
Ghosh, S. S., S. C. Bock, S. E. Rokita, and E. T. Kaiser (1986), "Modification of the Active Site of Alkaline Phosphatase by Site-Directed Mutagenesis", Science 231:145-148.
Moks et al, Eur. J. Bioch., 156, 637-43, (1986).
Kepplinger Esther L.
Kushan Jeff
Repligen Corporation
LandOfFree
Protein A domain mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein A domain mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein A domain mutants will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1862116