Protein A based binding domains with desirable activities

Details Protein A based binding domains with desirable activities Protein A based binding domains with desirable activities

2007-01-16

2007-01-16

Housel, James C (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S282100, C514S002600, C530S350000

Reexamination Certificate

active

09979383

ABSTRACT:
Provided are Staphylococcal protein A (SpA) variants for binding immunoglobulin (Ig), comprising a polypeptide which varies by one or more amino acids from the amino acid sequence of a natural variable heavy chain III (“VH3”) Ig-Fab binding region (“binding region”) of SpA, wherein the polypeptide exhibits a different binding specificity for Ig-Fab than does SpA or exhibits a different binding specificity for a non-Ig target molecule than does SpA. Further provided are methods of making the variants and methods of using the variants for in purification of Ig as well as diagnostic and therapeutic intervention.

REFERENCES:
patent: 4879378 (1989-11-01), Foster et al.
patent: 5100788 (1992-03-01), Löfdahl et al.
patent: 5189014 (1993-02-01), Cowan, Jr.
patent: 5198531 (1993-03-01), Webber et al.
patent: 5240680 (1993-08-01), Zuckermann et al.
patent: 5831012 (1998-11-01), Nilsson et al.
patent: 5837500 (1998-11-01), Ladner et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 5977322 (1999-11-01), Marks et al.
patent: 5993816 (1999-11-01), Lederman et al.
patent: 6013763 (2000-01-01), Braisted et al.
patent: 6031071 (2000-02-01), Mandeville et al.
patent: 6060596 (2000-05-01), Lerner et al.
patent: 6440418 (2002-08-01), Black et al.
patent: 6447777 (2002-09-01), Terman et al.
Akerstrom, et al., “On the interaction between single chain Fv antibodies and bacterial immunoglobulin-binding proteins,”Journal of Immunological Methods, 177:151-163 (1994).
Allman, et al., “Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics.”J. Immunol., 149:2533-2540 (1992).
Alting-Mees, et al., “Polycos vectors: a system for packaging filamentous phage and phagemid vectors using lambda phage packaging extracts,”Gene, 137:93-100 (1993).
Bachmann, et al., “The influence of antigen organization on B cell responsiveness,”Science, 262:1448-1451 (1993).
Barbas, et al., “In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity,”Proc.Natl.Acad.Sci.U.S.A., 91:3809-3813 (1994).
Berberian, et al., “A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest,”Blood, 78:175-179 (1991).
Berberian, et al., “Immunoglobulin VH3 gene products: natural ligands for HIV gp120,”Science, 261:1588-1591 (1993).
Boekel, et al., “Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression,”Immunity, 8:199-207 (1998).
Braden, et al., “Anatomy of an antibody molecule: structure, kinetics, thermodynamics and mutational studies of the antilysozyme antibody,” D1.3.Immunol Rev., 163:45-57 (1998).
Braisted, et al., “Minimizing a binding domain from protein A,”Proc. Natl. Acad. Sci. USA, 93:5688-5692 (1996).
Brodeur, et al., “The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes,”Eur.J.Immunol., 14:922-930 (1984).
Brown, et al., “Specific suppression of the antibody response in vitro by serum from paralyzed mice,”J.Immunol., 115:419-424 (1975).
Chothia, et al., “Canonical structures for the hypervariable regions of immunoglobulins,”J. Mol. Biol., 196:901-917 (1987).
Cwirla, et al., “Peptides on phage: A vast library of peptides for identifying ligands,”Proc. Natl. Acad. Sci. USA, 87:6378-6382 (1990).
Demaison, C., “V(H) gene-family representation in peripheral activated B cells from systemic lupus erythematosus (SLE) patients,”Clin.Exp.Immunol., 104:439-445 (1996).
Desaymard, et al., “Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopes,”Mol. Immunol., 21:961-967 (1984).
Devlin, et al., “Random peptide libraries: A Source of specific protein binding molecules,”Science, 249:404-406 (1990).
Djojonegoro, et al., “Bacteriophage surface display of an immunoglobulin-binding domain ofStaphylococcus aureusprotein A,”Biotechnology(N. Y.)., 12:169-172 (1994).
Drew, M.J., “Resolution of refractory, classic thrombotic thrombocytopenic purpura after staphylococcal protein A immunoadsorption,”Transfusion, 34:536-538 (1994).
Endresen, C., “The binding of protein A of immunoglobulin G and of Fab and Fc fragments,”Acta.path.microbiol.scand., Sect. C:185-189 (1979).
Feeney, A.J., “Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences,”J.Exp.Med., 172:1377-1390 (1990).
Feeney, A.J., “Predominance of the prototypic T15 anti-phosphorylcholine junctional sequence in neonatal pre-B cells,”J. Immunol., 147:4343-4350 (1991).
Feijo, et al., “Variable region strucure and Staphylococcal protein A binding specificity of a mouse monoclonal IgM anti-laminin-receptor antibody,”Immunology, 91:479-485 (1997).
Fields, et al., “Crystal structure of a T-cell receptor beta-chain complexed with a superantigen [see comments],”Nature, 384(6605):188-92 (1996).
Goodnow, et al., “Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice,”Nature, 334:676-682 (1988).
Granzow, et al., “Interactions in the fourth dimension,”Bio/Technology, 10:390 (1992).
Hakoda, et al., “Molecular basis for the interaction between human IgM and staphylococcal protein A,”Clin. Immunol. Immunopathol., 72:394-401 (1994).
Hashimoto, et al., “Superantigens and autoantigens may be involved in the pathogenesis of gastric mucosa-associates lymphoid tissue lymphoma,”Int. J Hematol., 74(2):197-204 (2001).
Hillson, et al., “The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A,”J. Exp. Med., 178:331-336 (1993).
Ibrahim, et al., “Proportion of protein A bindable molecules in human IgM and IgA antibodies to seven antigens,”Microb.Pathog., 15:159-168 (1993).
Ibrahim, et al., “V-region-mediated binding of human Ig by protein A,”J. Immunol., 151:3597-3603 (1993).
Inganas, M., “Comparison of mechanisms of interaction between protein A fromStaphylococcus aureusand human monoclonal IgG, IgA and IgM in relation to the classical Fc gamma and the alternative F(ab′)2 epsilon protein A interactions,”Scand. J. Immunol.13:343-352 (1981).
Ito, et al., “A general method for introducing a series of mutations into cloned DNA using the polymerase chain reaction,”Gene, 102:67-70 (1991).
Jansson, et al., “All individual domains of staphylococcal protein A show Fab binding,”FEMS. Immunol. Med. Microbiol., 20:69-78 (1998).
Kabat, et al., “Unusual distributions of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites,”J Biol Chem, 252(19), 6609-16 (1977).
Kavaler, et al., “A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response,”Eur. J. Immunol., 21:2687-2695 (1991).
Kirkham, et al., “Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding,”EMBO J., 11:603-609 (1992).
Knappik, et al., “Fully synthetic human combinatorial antibody libraries (huCAL) based on molecular consensus frameworks and CDRs randomized with trinucleotides,”J. Mol. Biol., 296:57-86 (2000).
Kotzin, et al., “Superantigens and their potential role in human disease,”Adv Immunol, 54:99-166. (1993).
Kozlowski, et al., “Staphylococcus aureusCowan I-induced human immunoglobin responses: Pref

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