Protein

Details Protein Protein

2006-02-21

2006-02-21

Smith, Lynette R. F. (Department: 1645)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

C435S006120, C435S252300, C435S254100, C424S184100, C424S185100, C424S274100, C514S002600, C514S015800, C536S023100, C536S023700

Reexamination Certificate

active

07001757

ABSTRACT:
This invention relates to polynucleotides, polypeptides encoded by these polynucleotides, to the production of such polynucleotides and polypeptides, and to the uses of such polynucleotides and polypeptides. More specifically, the invention relates to the phosphomevalonate kinase (PMK) gene (ERG8 gene) fromCandida Albicans(C. albicans), to methods for its expression yielding phosphomevalonate kinase protein, to hybrid organisms for use in such expression methods, to methods for purification of the protein, to methods and tools for diagnosingC. albicansinfection and to assays for identifying inhibitors of the enzyme which inhibitors have potential as anti-fungal agents.

REFERENCES:
patent: 5885815 (1999-03-01), Kaufmann et al.
Bowie et al. Science, vol. 247: 1990; p. 1306; p. 1308.
Houghten et al. (Vaccines, 1986, Edited by Fred Brown: Cold Spring Harbor Laboratory).
Accession No.: M63648.
Tsay, et al., “Cloning and characterization of ERG8, an essential gene ofSaccharomyces cerevisiaethat encodes phosphomevalonate kinase” Molecular and Cellular Biology, vol. 11, No. 2, Feb. 1991, pp. 620-5631, XP000981936.
Lees et al., “Biochemistry and molecular biology of sterol synthesis inSaccharomyces cerevisiae”, Critical Reviews in Biochemistry and Molecular Biology, vol. 34, No. 1, Jan. 1999, pp. 33-47, XP000981947.
Hartman et al., “Inhibitors of ergosterol biosynthesis as antifungal agents”, Current Pharmaceutical Design, vol., 3, No. 2, Apr. 1997, pp. 177-208, XP000981960.
Jensen-Pergakes et al., “Sequencing disruption and characterization of theCandida albicanssterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants”, Antimicrobial Agents and Chemotherapy, vol. 42, No. 5, May 1998, pp. 1160-1167.
Kelly et al., “Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene ofCandida albicans”, GENE, vol. 87, No. 2, Mar. 1990, pp. 177-183, XP992160270.
Mannarelli et al., “Rapid identification ofCandida albicansand other human pathogenic yeasts by using short oligonucleotides in PCR”, Journal of Clinical Microbiology, vol. 36, No. 6, Jun. 1998, pp. 1634-1641, XP002160271.

Affiliated with

Also associated with

Rating

Protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3638777