Protective monoclonal antibody compositions for infections due t

Details Protective monoclonal antibody compositions for infections due t Protective monoclonal antibody compositions for infections due t

1988-05-02

1990-11-13

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 530387, 530388, 530389, 530808, 530809, 435 7021, 43524026, 43524027, 4352402, 435948, 436548, 935100, 935104, 935107, 935110, A61K 3940, C07K 1528, C12N 510

Patent

active

049700707

ABSTRACT:
Immortalized cell lines have been produced that secrete human monoclonal antibodies capable of binding to bacterial species which are a major cause of neonatal sepsis and meningitis. These antibodies have been found to be protective against lethal challenges of these bacteria, which include group B streptococcus, E. coli, K1, and Neisseria meningitidis group B. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal anitbodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.

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