Protective four amino acid epitope against Plasmodium vivax mala

Details Protective four amino acid epitope against Plasmodium vivax mala Protective four amino acid epitope against Plasmodium vivax mala

1990-11-06

1992-03-10

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

514895, A61K 3700

Patent

active

050950932

ABSTRACT:
A synthetic peptide of the human malaria Plasmodium vivax, containing at st one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human maleria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.

REFERENCES:
patent: 4466917 (1984-08-01), Nussenzweig et al.
patent: 4693994 (1987-09-01), McCutchan et al.
patent: 4707357 (1987-11-01), Dame et al.
patent: 4826957 (1989-05-01), Nussenzweig et al.
patent: 4957869 (1990-09-01), Arnot et al.
Collins et al., Am. J. Trop. Med. Hyg., 40(5), 1989, pp. 455-464.
Fundamental Immunology, William E. Paul, ed., pp. 975-977 (1989).

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