Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-11-10
1984-09-25
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424 81, 424250, 424315, A61K 2700, A61K 31185, A61K 31495
Patent
active
044735693
ABSTRACT:
A protective composition is provided for application to the skin (especially the hands) of persons working with cyanoacrylate adhesive compositions ("superglues" ), to prevent accidental adhesion of skin to skin or to other substrates. The composition comprises a skin-compatible adhesion-inhibiting substance for cyanoacrylate monomers, the substance being incorporated in a conventional topical pharmaceutical base to produce, e.g., a skin cream. Any cyanoacrylate monomer-stabilizer which is kind to the skin can be used, but in addition a group of named zwitterionic aminosulfonic acids ("ZASA's") is proposed and preferred for the purpose. They have a preferred pK.sub.a at in the range of 6.0-8.3 at 20.degree. C.
REFERENCES:
patent: 3873467 (1975-03-01), Hunt
patent: 4057535 (1977-11-01), Lipatova et al.
patent: 4246194 (1981-01-01), Furguson
patent: 4251387 (1981-02-01), Lim et al.
Good et al., Biochemistry, 1966, vol. 5, pp. 467-477.
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