Protection of the gastric mucosal lining from damage by aspirin

Details Protection of the gastric mucosal lining from damage by aspirin Protection of the gastric mucosal lining from damage by aspirin

1978-11-03

1984-04-03

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

A61U 3160

Patent

active

044407629

ABSTRACT:
A formulation which allows administration of aspirin and like drugs and avoids gastrointestinal damage to a significant extent is described. A preferred formulation particularly useful for protecting the gastric mucosal lining of arthritic sufferers on a prolonged aspirin medication program comprises aspirin, glucose and sodium acetate or sodium citrate. A like composition containing dibromoaspirin in lieu of aspirin is helpful in reducing gastrointestinal damage to persons suffering from sickle cell disease and who regularly take dibromoaspirin.

REFERENCES:
Sorokina et al. (Sorokina), Chem. Abstr. 80:5233g(1974).
Moustafa et al. (Moustafa), Chem. Abstr. 85 112717a(1976).
Javaid et al. (Javaid), Chem. Abstr. 77:130533b(1972).
Jue et al., Journal of the Pharm. Ass. pp. 470, 471 & 474 9/63.
Merck Index 7th Ed. (1960) 949-950.
Chem. Abst. (A) 85-140574v(1976).
Chem. Abst. (B) 81-88713r(1974).
Chem. Abst. (C) 68-58407h(1968).
Chem. Abst. (D) 70-50481y(1969).

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