Protection of teleost fish

Details Protection of teleost fish Protection of teleost fish

1994-10-11

1997-01-14

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424606, 424646, 424665, 423462, A61K 3900, A01N 5926, C01B 700

Patent

active

055936784

ABSTRACT:
Utility of protein phosphatase inhibitors to protect teleost fish from microorganismic pathogens is disclosed. The present invention provides pharmaceutical compositions, kits, and methods of therapeutic and prophylactic treatments comprising sodium orthovanadate or vanadate-mimetic protein phosphatase inhibitors to protect fish, for example, catfish, from infection and disease caused by microorganismic pathogens, e.g., Edwardsiella. Sodium orthovanadate, a protein phosphatase inhibitor, and vanadate-mimetic protein phosphatase inhibitors activate in vitro and in vivo the cytotoxicity of teleost nonspecific cytotoxic cells (NCC).

REFERENCES:
Evans, D. L. and Jaso-Friedmann, L. (1994) "Role of Protein Phosphatases in the Regulation of Nonspecific Cytotoxic Cell Activity," Developmental and Comparative Immunology, 2 (vol. 18):137-146.
Jaso-Friedmann, L. et al. (1994) "Pathways of Signaling in Nonspecific Cytotoxic Cells: Effects of Protein Kinase and Phosphatase Inhibitors and Evidence for Membrane Tyrosine Phosphorylation," Cellular Immunology, 1(vol. 153):142.
Evans, D. L. et al. (1990) "Pathways of Signal Transduction in Teleost Nonspecific Cytotoxic Cells," Developmental and Comparative Immunology, 14:295-304.
Jaso-Friedmann, L. et al. (1993) "Nonspecific Cytotoxic Cells in Fish: Antigens Cross-Reactivity of a Function Associated Molecule with the Intermediate Filament Vimentin," Cellular Immunology, 148:208-217.
Evans, D. L. et al. (1993) "Identification of a Vimentin-Like Function Associated Molecule (FAM) on Rat NK Cells: Evidence for Receptor Function," Scand. J. Immunol., 37:131-142.
Graves, S. S. et al. (Jan. 1985) "Antiprotozoan Activity of Nonspecific Cytotoxic Cells (NCC) from the Channel Catfish (Ictalurus Punctatus)", The Journal of Immunology, 1(vol. 134):78-85.
Alexander, D. R. (Dec. 1990), "The Role of Phosphatases in Signal Transduction," The New Biologist, 12(vol. 2):1049-1062.
Fischer, E. H. et al, (Jul. 26, 1991) "Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes," Articles, pp. 401-406.
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