Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1989-07-21
1993-03-30
Lacey, David L.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
4352401, 4352402, 43524021, 43524025, 514885, 604 4, 604 5, 604 6, A01N 102, A61K 3514, C12N 508
Patent
active
051983346
ABSTRACT:
Leucinol, phenylalaninol and benzamide protect against loss of Natural Killer activity when Peripheral Blood Mononuclear Cells are treated with an ester of an amino acid or dipeptide or an amide of an amino acid prior to incubation with IL-2 to generate Lymphokine-Activated Killer activity.
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Leung: Cancer Immunol. Immunotherap. 30: 247-253 (1989).
Leung Cancer Immunol Immunotherap 34: 31-36 (1991).
Imir et al, "Generation of Natural Killer Cells and Lymphokine-Activated Killer cells in human AB Serum or Fetal Bovine Serum", Clinical Immunology and Immunopathology V. 36, 289-296 (1985).
Restow et al, "In vitro effects of protease inhibitors on murine natural Killer cell Activity", Immunology, V. 48, pp. 1-8, 1983.
Hoyer et al. (1986), Cancer Research 46:2834-2838.
Thiele et al. (1985), J. Immunol. 144:786-793.
Leung, Lymphokine Research, vol. 6, Abstract No. 1718 (1987).
Gambel Phillip
Lacey David L.
Terumo Corporation
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