Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Patent
1997-12-04
1999-10-19
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
424 111, 424 93, 424 9322, 424422, A61K 900
Patent
active
059685271
ABSTRACT:
Methods and apparatus are described to inhibit the adverse health effects of ischemia, hypoxia, anoxia or other stress by the application of a time-varying field to the region of the affected organ(s) for a short period of time (of the order of 20 minutes). A "field" means a time varying electric field, a time varying magnetic field and/or a radiating electromagnetic field. The exposure can be started up to two or more hours in advance of the ischemic event or other stress causing event. Inhibition occurs even if the field is applied after the onset of ischemic or anoxic stress.
REFERENCES:
patent: 3566877 (1971-03-01), Smith
patent: 3890953 (1975-06-01), Kraus
patent: 3893462 (1975-07-01), Manning
patent: 3911930 (1975-10-01), Hagfors
patent: 3952751 (1976-04-01), Yarger
patent: 4105017 (1978-08-01), Ryaby
patent: 4266532 (1981-05-01), Ryaby
patent: 4315503 (1982-02-01), Ryaby
patent: 4428366 (1984-01-01), Findl
patent: 4459988 (1984-07-01), Dugot
patent: 4535775 (1985-08-01), Brighton
patent: 4548208 (1985-10-01), Niemi
patent: 4561426 (1985-12-01), Stewart
patent: 4600010 (1986-07-01), Dugot
patent: 4616629 (1986-10-01), Moore
patent: 4622952 (1986-11-01), Gordon
patent: 4622953 (1986-11-01), Gordon
patent: 4654574 (1987-03-01), Thaler
patent: 4683873 (1987-08-01), Cadossi
patent: 4757804 (1988-07-01), Griffith
patent: 4794928 (1989-01-01), Kletschka
patent: 4798824 (1989-01-01), Belzer
patent: 4838269 (1989-06-01), Robinson
patent: 4873230 (1989-10-01), Belzer
patent: 4879283 (1989-11-01), Belzer
patent: 4920044 (1990-04-01), Bretan, Jr.
patent: 4932951 (1990-06-01), Liboff
patent: 5123898 (1992-06-01), Liboff
patent: 5131904 (1992-07-01), Markoll
patent: 5224922 (1993-07-01), Kurtz
patent: 5269746 (1993-12-01), Jacobson
patent: 5330410 (1994-07-01), Baylink
patent: 5338286 (1994-08-01), Abbott
patent: 5348945 (1994-09-01), Berberian
patent: 5366435 (1994-11-01), Jacobson
patent: 5387176 (1995-02-01), Markoll
patent: 5441495 (1995-08-01), Liboff
patent: 5453073 (1995-09-01), Markoll
patent: 5518496 (1996-05-01), McLeod
Heart and Stroke Facts, American Heart Association National Center, 1996, p. 1.
Bonventre JV, Mediators of Ischemic Renal Injury, Ann. Rev. Med 39, 1988, p. 531-544.
Ananthan J, Goldberg Al, Voelmy R, Abnormal Proteins Serve As Eukaryotic Stress Signals and Trigger the Activation of health shock Genes, Science 232, 1986, pp. 552-524.
Mestril r, Dillmann WH, Heat Shock Proteins and Protection Against Myocardial Ischemia, J Mol Cardiol 27, 1995, pp. 45-52.
Donnelly TJ, Sievers RE, Visem FLJ, Welch WJ, Wolfe CL, Heat Shock Protein Induction in Rat Hearts, Circulation 85, 1992, pp. 769-778.
Walker DM, Pasini E, Kucukogolu S, Lin JJC, Feramisco JR, Heat Stress Limits Infarct Size in the Isolated Perfused Rabbit Heart, Cardiovasc Res 27, 1993, pp. 962-967.
Li GC, Mak JY, Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance, Cancer Res 45, 1985, pp. 3816-3824.
Iwaki K, Chi SH, Dillman WH, Mestril R, Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress, Circulation 87, 1993, pp. 2023-2032.
Hutter MM, Sievers RE, Barbosa V, Wolfe CL, Heat shock protein induction in rat hearts: a direct correlation between the amount of heat shock protein induced and the degree of myocardial protection, Circulation 89, 1994, pp. 355-360.
Mestril RM, Chi SH, Sayen MR, O'Reilly K, Dilllman WH, Expression of inducible stress portein in rat heart myogenic cells confers protection against simulated ischemia induced injury, J Clin Invest 93, 1994, pp. 759-769.
Heads RJ, Yellon DM, Latchman DS, Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells, J Mol Cell Cardiol 27, 1995, pp. 1669-1678.
Joannidis M, Cantley LG, Spokes K, Medina R, Pullman J, Rosen, Epstein FH, Induction of heat shock proteins does not prevent renal tubular injury following ischemia, Kidney Int.
Marber M, Mestril R, Chi SH, Sayen MR et al. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury, J Clin Invest. 95, 1995, pp. 1446-1456.
McLeod KJ, Lee RC, Ehrlich HP, Frequency dependence of electric field modulation of fibroblast protein synthesis, Science Jun. 12; 236(4807), 1987, pp. 1465-1469.
Goodman R, Henderson A, Patterns of transcription and translation in cells exposed to EM fields: A review. Mechanistic Approaches to Interactions of Electric and Electromagnetic Fields with Living Systems, Ed Martin Blank and Eugene Pindl, Plenum Publishing Corp.. 1987, pp. 217-230.
Goodman R, Henderson AS, Exposure of salivary gland cells to low-frequency electromagnetic fields alters polypeptide synthesis. Proc Natl Acad Sci USA Jun; 85(11), 1988, pp.3928-3932.
Blank M, Goodman R, An electrochemical model for the stimulation of biosynthesis by external electric fields, Bioelectrochem and Bioenerg. 19, 1998, pp. 569-580.
Albertini A, Noera G, Pierangeli A, Zucchini P, Cadossi R, Effect of low-frequency pulsed electromagnetic fields on experimental myocardial infarcts in rats, Electromagnetics in.
Edgington SM, Therapeutic applications of Heat Shock Proteins, Biotechnology 13, 1995, pp. 1442-1444.
Sedlak BJ, Heat Shock proteins finding a broad range of clinical uses and applications, Genetic Eng. News 17(3), 1966, p. 6.
Lee BS, Chen J, Angelidis C, Jurivich DA, Morimoto RI, Pharmacological modulation of heat shock factor by anti-inflammatory drugs results in protection against stress-induced cellular damage, Proc Natl Acad Sci USA, Aug 92(16), 1995, pp. 7202-7211.
Chapter 9, Biomagnetic Effects, a part of NMR Imaging in Biomedicine, Mansfield et al., Academic Press, Apr. 13, 1982, pp. 297-310.
Liboff, AR, Cyclotron Resonance in Membrane Transport, a part of Interactions Between Electromagnetic Fields and Cells, Chiabrerra et al., Plenum Publishing, 1985, pp. 281-296.
Catholic University of America, The
Dees Jos,e G.
Shelborne Kathryne E.
LandOfFree
Protection of living systems from the adverse effects of stress does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protection of living systems from the adverse effects of stress, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protection of living systems from the adverse effects of stress will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2052284