Protection of labile proteins during iodine disinfection

Details Protection of labile proteins during iodine disinfection Protection of labile proteins during iodine disinfection

1998-09-01

2000-04-04

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

424480, 424488, 424667, 424668, A61K 3179, A61K 936, A61K 914, A61K 3336

Patent

active

060457872

ABSTRACT:
Mixtures of iodine source resin with iodine capture resin have been found to provide effective disinfecting of protein containing solutions such as plasma. These mixtures can be used in a chromatographic manner to effectively disinfect solutions while causing minimal damage to labile proteins such as clotting factors. Mixed resins containing equivalent amount of iodine source and iodine capture (50:50) are effective in many cases. If protein damage is still occurring, the ideal mixture may be one containing a lower amount of iodine (e.g. 25:75 or even 5:95). If disinfecting properties prove inadequate, ratios can be increased (e.g. 80:20). Surprisingly, the mixed resins also spare tissue components such as red blood cells and platelets. In some cases mixed resins are even useful in a batch procedure where the resin is removed by centrifugation or filtration at the end of a treatment period.

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