Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1991-08-14
1992-11-24
Rosen, Sam
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
4352401, 4352402, A01N 102
Patent
active
051660482
ABSTRACT:
The cells of the coverings and linings of internal human and animal tissues, organs and body cavities subject to trauma, such as surgery, may be protected against exfoliation or destruction by the topical application or injection of effective amounts of chondroitin sulfate prior to or during the trauma. Preferably, the chondroitin sulfate is used in physiological solutions in concentrations of about 40 to 55 weight percent, and may be used as a surgical irrigating solution. Intraarticular injection of such chondroitin sulfate solutions into human and animal joints having degenerative joint conditions protects the joint cells, reduces aseptic inflammation and/or prevents further degeneration of cartilage tissue. Solutions for preserving human and animal cells and tissues in vitro for later in vivo use have extended storage life when chondroitin sulfate is added to such storage solutions in effective amounts such as about 1 to 20 weight percent of the storage solution.
REFERENCES:
Kaufman et al--Am. J. of Ophthalmology--vol. 100 (Aug. 1985) pp. 299-304.
Kaufman et al--Am. J. of Ophthalmology vol. 98 (1984) pp. 112-114.
Mizukawa et al--Folio Ophthalmological Japonica vol. 19(12) (1968) pp. 1310-1318 (partial translation supplied).
Harrison Sol E.
Soll David B.
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