Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-02-05
1989-10-31
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514474, A61K 3135
Patent
active
048778109
ABSTRACT:
Administration of chroman, 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, prior to or simultaneously with resuming normal blood supply to the heart following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion of the heart.
REFERENCES:
patent: 3903317 (1975-09-01), Cort
patent: 3986980 (1976-10-01), Cort
S. Marubayashi et al., "Role of Free Radicals in Ischemic Rat Liver Cell Injury: Prevention of Damage by .alpha.-tocopherol Administration", Surgery 99, 184-192, (1986).
R. Ferrari et al., "Role of Oxygen in Myocardial Ischemic and Reperfusion Damage Effect of alpha-tocopherol", Acta Vitaminol. Enzymol 7 Suppl., 61-70 (1985), Medline Abst. No. 87045647.
A. F. Casini et al., "Liver Gluthatione Depletion Induce by Bromobenzene, Iodobenzene, and Diethylmaleate Poisoning and Its Relation to Lipid Peroxidation and Necrosis", Am. J. Pathol. 118, 225-237, (1985).
M. Khuzhamberdiev, "Activation of Lipid Peroxidation in Chronic Ischemic Heart Disease", Bull. Exp. Biol. Med. 100, 1179-1181, (1985).
"Evidence of Myocardial Free Radical Injury During Elective Repair of Tetralogy of Fallot", Circulation, vol. 76, Supplement V, Nov. 1987, pp. v174-v179.
"Free Radicals and Myocardial Ischemia and Reperfusion Injury", J. Lab. Clin. Med., Jul., 1987, pp. 13-30.
"Oxygen Free Radicals Linked to Many Diseases", Science, Research News, 30 Jan. 1987, pp. 529-531.
"Peroxy Free Radicals, Enzymes and Radiation Damage: Sensitisation by Oxygen and Protection by Superoxide Dismutase and Antioxidants", The British Journal of Radiology, 58, pp. 251-256, Mar., 1985.
"The Protective Effect of Vitamin E on Cerebral Ischemia", Surg. Neurol, 1984; 22, pp. 449-454.
"Reduction in Experimental Infarct Size by Recombinant Human Superoxide Dismutase: Insights Into the Pathophysiology of Reperfusion Injury", Circulation 74, No. 6, pp. 1424-1433.
"Antioxidant and co-Antioxidant Activity of Vitamin C. The Effect of Vitamin C, Either Alone or in the Presence of Vitamin E or a Water-Soluble Vitamin E Analogue, Upon the Peroxidation of Aqueous Multilamellar Phospholipid Liposomes", Biochimica et Biophysica Acta 835, 1985, pp. 298-303.
Mickle Donald A. G.
Wu Tai-Wing
Eastman Kodak Company
Newman Irving
Waddell Frederick E.
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