Protection from loss of sensory hair cells in the inner ear by a

Details Protection from loss of sensory hair cells in the inner ear by a Protection from loss of sensory hair cells in the inner ear by a

1999-08-18

2000-10-24

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 530399, 435 6, 435 78, A61K 3800

Patent

active

061367850

ABSTRACT:
The invention relates to a method for protecting sensory hair cells of the inner ear from damage caused by ototoxic drugs, in particular, aminoglycoside antibiotics, by administering to a vertebrate a growth factor, or mixture thereof. Additionally, the method protects against loss of sensory hair cells as a result of aging. In particular, the growth factor is an insulin-like growth factor or platelet-derived growth factor. The invention also relates to a method for detecting protection against an ototoxic drug on sensory hair cells of an inner ear of a vertebrate by a growth factor or biologically active fragment.

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