Protection against rhabdomyolysis-induced nephrotoxicity

Details Protection against rhabdomyolysis-induced nephrotoxicity Protection against rhabdomyolysis-induced nephrotoxicity

1990-11-30

1992-02-25

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

In vivo diagnostic or in vivo test agent which contains an...

514592, 514708, 514936, 514568, 514575, 514 2, A61K 3750

Patent

active

050911805

ABSTRACT:
The present invention is directed to the in vivo use of compounds which prevent the generation of, effectively scavenge, or detoxify a reactive oxygen metabolite that mediates a toxic effect of rhabdomyolysis and myoglobinuria. The compounds of the invention can be used to prevent or reduce rhabdomyolysis-induced renal damage, and include but are not limited to free radical scavengers, iron chelators, oxidizable compounds, enzymes which metabolize reactive oxygen metabolites or their precursors, and biosynthetic precursors thereof.

REFERENCES:
Baud et al. Am. J. Physiol. 251: F765-F776.

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