Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-24
2007-07-24
Saidha, Tekchand (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023400, C435S004000, C435S252300, C435S320100, C435S006120, C530S350000
Reexamination Certificate
active
10271429
ABSTRACT:
This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.
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Venugopal, et al., “Nrf1 and Nrf2
Chen Xilin
Kunsch Charles
Luchoomun Jayraz
Varner Signe E.
Atherogenics, Inc.
King & Spalding
Pak Yong D.
Saidha Tekchand
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