Protection against liver damage by HGF

Details Protection against liver damage by HGF Protection against liver damage by HGF

1995-05-26

1997-12-30

Feisee, Lila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514893, 514894, 514838, 530350, 530399, 435360, 935 13, A61K 3818, C07K 14475, C12N 1512, C07H 2104

Patent

active

057030480

ABSTRACT:
The present invention provides methods for preventing occurrence or progression of liver damage using hepatocyte growth factor. In the methods, a preventatively effective amount of the hepatocyte growth factor is administered to the patient. The hepatocyte growth factor can be administered, for instance, prior to administering a hepatotoxic therapy to the patient. The hepatocyte growth factor can further be administered with activin or transforming growth factor-beta to prevent liver damage. Compositions comprising hepatocyte growth factor and activin antagonist or transforming growth factor-beta antagonist are also provided by the invention.

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Russell WE et al.Proc Natl Acid Sci 85: 5126-5130 (1988).
Hernandez J et al. 1992 J. Cell. Phys. 150:116-121.

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