Protection against dental caries

Details Protection against dental caries Protection against dental caries

1982-06-15

1984-04-10

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Dentifrices

260112R, 424 88, 424 92, 424 85, 424 87, A61K 716, A61K 3900, A61K 3909, C07G 700

Patent

active

044420854

ABSTRACT:
An antigenic protein, termed antigen A, present on the cell walls and in tures of Streptococcus mutans, especially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notably those which cross-react with heart tissue, to give an antigenic preparation which may be used as a vaccine or to raise antibodies for use in protecting against dental caries.
Antigen A is one of two major antigenic proteins remaining on cell walls of S. mutans genetic group I after extraction with a boiling 10 g/l liter aqueous solution of sodium dodecyl sulphate for 20 minutes. It has a molecular weight of about 29,000, an isoelectric point of 4.1 to 4.5. Its amino-acid analysis is also given.
The antigen also occurs in the culture filtrate and/or cell extract and may be readily purified from these sources by, for example fractional ammonium sulphate precipitation and/or affinity chromatography on immobilized antibody.

REFERENCES:
Russell, J. Dent Res., vol. 55, (Spec. Issue), pp. D122, 1976.
Russell et al., Arch. Oral. Biol., vol. 23, pp. 7-15, 1978.
Iacono et al., Infection and Immunity, vol. 11, pp. 117-128, 1975.
Bratthall et al., J. Dent. Res.

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