Protection against dental caries

Details Protection against dental caries Protection against dental caries

1981-09-18

1984-05-15

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 68, 424 50, 424 49, 424 88, 260112R, A61K 3909, C12P 2100

Patent

active

044487681

ABSTRACT:
An antigenic protein, termed antigen A, present on the cell walls and in tures of Streptococcus mutans, especially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notably those which cross-react with heart tissue, to give an antigenic preparation which may be used as a vaccine or to raise antibodies for use in protecting against dental caries.
Antigen A is one of two major antigenic proteins remaining on cell walls of S. mutans genetic group I after extraction with a boiling 10 g/l liter aqueous solution of sodium dodecyl sulphate for 20 minutes. It has a molecular weight of about 29,000, an isoelectric point of 4.1 to 4.5. Its amino-acid analysis is also given.
The antigen also occurs in the culture filtrate and/or cell extract and may be readily purified from these sources by, for example fractional ammonium sulphate precipitation and/or affinity chromatography on immobilized antibody.

REFERENCES:
Russell, M., et al., Arch. Oral. Biol., vol. 23, pp. 7-15, 1978.
Iacono, V., et al., Injection and Immunity, vol. 11, pp. 117-128, 1975.

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