Protecting group for synthesizing oligonucleotide analogs

Details Protecting group for synthesizing oligonucleotide analogs Protecting group for synthesizing oligonucleotide analogs

1997-09-18

1998-07-21

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

558 96, 558108, 558110, 558171, C07H 102, C07F 902, C07F 908

Patent

active

057836906

ABSTRACT:
A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.

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