Protected linker compounds

Details Protected linker compounds Protected linker compounds

2007-01-16

2007-01-16

Peselev, Elli (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025400, C544S243000, C544S244000, C548S414000

Reexamination Certificate

active

10256510

ABSTRACT:
The invention features linker molecules that have at one terminus a amino-protecting group and at the other terminus a phosphorous activating group, typically phosphoramidite. The linker molecules can be used, for example, to produce amino-modified linkers that space an oligonucleotide from a solid support. The invention also features an amino-protected nucleotide that includes an activated phosphorous group such as a phosphoramidite for the production of a 5′ amino-modified oligonucleotide. The invention further provides a phthalimido-modified support that can be used to synthesize a polynucleotide that includes an amino group at the 3′ terminus.

REFERENCES:
patent: 5039819 (1991-08-01), Kieczykowski
Aronov and Gelb, “Phthalimide Resin Reagent for Efficient Mitsunobu Amino-Dehydroxylation”,Tetrahedron Letters39:4947-4950 (1998).
Bressi et al., “Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase ofTrypanosomatidaevia Structure-Based Drug Design”,J. Med. Chem. 44:2080-2093 (2001).

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