Protected formylpentanediols, hydroxymethylpentanediols, process

Details Protected formylpentanediols, hydroxymethylpentanediols, process Protected formylpentanediols, hydroxymethylpentanediols, process

1992-10-30

1993-12-28

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

549349, 549350, 549360, 549363, C07F 718, C07D32100, C07D31900

Patent

active

052741575

ABSTRACT:
Compounds of the formula Ib ##STR1## in which R.sub.1 and R.sub.2 independently of one another are linear or branched C.sub.1 -C.sub.12 alkyl, cycloalkyl having 5 to 8 ring carbon atoms, phenylalkyl having 1 to 4 C atoms in the alkylene group, the cyclic radicals being unsubstituted or substituted by C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, or R.sub.1 and R.sub.2 independently of one another are --SiR.sub.4 R.sub.5 R.sub.6 in which R.sub.4, R.sub.5 and R.sub.6 independently of one another are C.sub.1 -C.sub.12 alkyl, phenyl, benzyl, or phenyl or benzyl, each of which is substituted by C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, and R.sub.3 is a bridging member which, together with the radical --OCH--CH.sub.2 --CHO-- to which it is bonded, forms a 6- to 8-membered ring. These compounds are valuable intermediates for the preparation of carbacyclic nucleosides of the natural and unnatural series and of the racemates.

REFERENCES:
Synthesis; No. 9; Sep. 1985; pp. 817-845.
Tet. Lett.; vol. 27; No. 6; 1986, pp. 747-748.
J. Med Chem., vol. 32; pp. 1861-1865 (1989).
J. Med Chem. vol. 33; pp. 1353-1360 (1990).
Nucleosides & Nucleotides, 6 (182), pp. 233-237 1987.
Tetrahedron Letters, vol. 31, No. 10 pp. 1463-1466 (1990).
J. Chem. Soc. Chem. Commun pp. 1083-1084 (1987).
J. Org. Chem. vol. 54, 5268-5272, Inoue et al., 1989.
Tetrahedron Letters, vol. 27, No. 6, pp. 747-748 (1986) Ravenscroft, P. et al.
Synthesis, No. 9, 1985, pp. 817-845, Lalonde, M. et al.

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