Protected biotin derivatives

Details Protected biotin derivatives Protected biotin derivatives

1988-08-23

1993-09-21

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540542, 544139, 544276, 544277, 546199, 546 21, 548113, 536 2532, C07D23340, C07F 909

Patent

active

052470814

ABSTRACT:
Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesizer. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

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patent: 4908453 (1990-03-01), Cocuzza
Bannwarth, Helvetica Chimica Acts, vol. 68, (7), 1985 pp. 1907-1912.
Ohtsuka, et al Nucleic Acid Res. 10(21) 1982 pp. 6553-6570.
Sinha et al Nucleic Acid Res. 12(11) 1984 pp. 4539-4557.
Fourney, et al. Tetrahetron Letters 25(40) 1984 pp. 4511-4515.
Nippon Soda, Chemical Abstracts vol. 83 1975, Abstract 28226v.
Chimia. 41(5), 1987 pp. 148-150.

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