Protected amino acids and process for the preparation thereof

Details Protected amino acids and process for the preparation thereof Protected amino acids and process for the preparation thereof

1990-04-13

1994-06-28

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

552104, 548256, 5482624, 560 39, 560 41, 562441, C07D25304, C07D48704, C07C22924

Patent

active

053248333

ABSTRACT:
Compounds of the formula I, ##STR1## in which 'R.sub.1 is an amino protective group, and n stands for 1 or 2, R.sub.1 denotes hydrogen or an amino protective group, R.sub.2 denotes hydrogen or a carboxyl protective group and R.sub.3 denotes triphenylmethyl, 4-monomethoxy-trityl or 4,4'-dimethoxy-trityl, and reactive carboxylic acid derivatives of such compounds of the formula I in which R.sub.2 stands for hydrogen, are described.
These compounds can be used as starting materials for the preparation of peptides. They are more suitable for this than are analogous compounds of the formula I in which R.sub.3 denotes hydrogen or one of the carbamoyl protective groups hitherto customary.

REFERENCES:
patent: 4871870 (1989-10-01), Kim
K. Okawa et al., Chem. Abstract, vol. 93, p. 26820, Abst. No. 93:26813n. (1960).
S. Wang et al., "Facile Synthesis of Amino Acid and Peptide Esters under Mild Conditions via Cesium Salts", J. Org. Chem., vol. 42, No. 8, 1977, pp. 1286-1290.
Sieber and Riniker, copy of poster at Symposium on Solid Phase Synthesis in Oxford UK, on Aug. 29-Sep. 2, 1989.
Houben-Weyl, "Methoden der Organischen Chemie," 4th ed. vol. XV/1, Stuttgart 1974 pp. 711-727.
Sieber, et al. Tetrahedron Letters 28(1987) 6031-6034.
Weygand, et al. Chem. Ber 101(1968) 3642-3648.
Pietta, et al. Chem. Ber 101(1968) 3649-3651.
Konig, et al. Chem Ber 103(1970) 2041-2051.
Weygand et al. Chem. Ber. 101(1968) 3623-3641.

Affiliated with

Also associated with

Rating

Protected amino acids and process for the preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protected amino acids and process for the preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protected amino acids and process for the preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2378227