Proteasome inhibitors and methods of using the same

Details Proteasome inhibitors and methods of using the same Proteasome inhibitors and methods of using the same

2006-02-09

2008-12-23

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S408000, C546S335000, C548S571000

Reexamination Certificate

active

07468383

ABSTRACT:
The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly or indirectly with proteasome activity.

REFERENCES:
patent: 2005/0107307 (2005-05-01), Bernadini et al.
patent: 03059898 (2003-07-01), None
patent: 2005021558 (2005-03-01), None
Song et al., The Journal of Biological Chemistry, 1999, vol. 274, pp. 1677-1682.

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