Proteasome inhibitors

Details Proteasome inhibitors Proteasome inhibitors

2007-10-16

2010-11-23

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S349000, C544S406000, C564S008000, C564S155000, C560S029000, C514S064000, C514S249000, C514S252100

Reexamination Certificate

active

07838673

ABSTRACT:
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 5159060 (1992-10-01), Kinder et al.
patent: 5169841 (1992-12-01), Kleeman et al.
patent: 5780454 (1998-07-01), Adams et al.
patent: 5814622 (1998-09-01), De Nanteuil et al.
patent: 6846806 (2005-01-01), Priestley
patent: 6939854 (2005-09-01), Priestley
patent: 7119080 (2006-10-01), Adams et al.
patent: 2005/0107307 (2005-05-01), Bernadini et al.
patent: 2006/0084592 (2006-04-01), Boucher
patent: 0354522 (1990-02-01), None
patent: WO 01/02424 (2001-01-01), None
patent: WO 02/059131 (2002-08-01), None
patent: WO 2005/097809 (2005-10-01), None
patent: WO 2006/099261 (2006-09-01), None
patent: WO 2007/005991 (2007-01-01), None
patent: WO 2007/089618 (2007-08-01), None
patent: WO 2007/100374 (2007-09-01), None
Carter et al., Chemotherapy of Cancer, second edition, John Wiley & Sons, N.Y., N.Y., 1981, pp. 362-365.
International Search Report and Written Opinion dated Sep. 29, 2008 from International Application No. PCT/US2007/022079 corresponding to U.S. Appl. No. 11/974,758.
Lai, Jack H., et al., “Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors: Amino-Lactam boroAlanines,”Journal of Medicinal Chemistry, vol. 50, No. 10 (Apr. 26, 2007) pp. 2391-2398.
Lai, Jack H. et al., “Synthesis and Characterization of Constrained Peptidomimetic Dipeptidyl Peptidase IV Inhibitors: Amino-Lactam boroAlanines,”Journal of Medicinal Chemistry, vol. 50, No. 10, (2007), pp. 2391-2398.
Han, Wei et al., “7-Azabicycloheptane Carboxylic Acid: A Proline Replacement in a Boroarginine Thrombin Inhibitor,”Organic Letters, vol. 1, No. 12, (1999), pp. 1875-1877.
Coutts, Simon J. et al., “Structure-Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P2Position of Xaa-boroPro Dipeptides,”Journal of Medicinal Chemistry, vol. 39, (1996), pp. 2087-2094.
Tsu, Christopher, “Quantitation of Immunoproteasome Activity in Cells and Tissues Using Selective Substrates,” presented at3rdCharite Zeuthener, See Workshop Apr. 20-23, 2007.
International Search Report and Written Opinion dated Sep. 29, 2008 from International Application No. PCT/US2007/022079, which relates to U.S. Appl. No. 11/974,758, filed Oct. 16, 2007.

Affiliated with

Also associated with

Rating

Proteasome inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Proteasome inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteasome inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4231716