Proteasome inhibitors

Details Proteasome inhibitors Proteasome inhibitors

2011-08-23

2011-08-23

Witherspoon, Sikarl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Boron acids or salts thereof

C562S450000, C564S008000, C564S169000, C514S064000

Reexamination Certificate

active

08003819

ABSTRACT:
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 5159060 (1992-10-01), Kinder et al.
patent: 5580486 (1996-12-01), Labeque et al.
patent: 6060462 (2000-05-01), Galemmo, Jr. et al.
patent: 7442830 (2008-10-01), Olhava et al.
patent: 2005/0107307 (2005-05-01), Bernadini et al.
patent: WO 96/13266 (1990-05-01), None
patent: WO 02/059131 (2002-08-01), None
patent: WO 03/059898 (2003-07-01), None
patent: WO 2005/097809 (2005-10-01), None
patent: WO 2007/005991 (2007-01-01), None
Kinder, David H., et al., “Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase,”Journal of Medicinal Chemistry, vol. 28, No. 12 (1985) pp. 1917-1925.
Tran, Thuy, et al., “Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP,”Bioorganic&Medicinal Chemistry Letters, vol. 17 (2007) pp. 1438-1442.
International Search Report and Written Opinion dated Dec. 3, 2007 in International Application No. PCT/US07/017440 which corresponds with U.S. Appl. No. 11/890,412.
Gardner, Robert C., et al., “Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells,”Biochemistry, vol. 346 (2000) pp. 447-454.
Kisselev, Alexei F., et al., “Proteasome inhibitors: from research tools to drug candidates,”Chemistry&Biology, vol. 8, No. 8 (2001) pp. 739-758.
Loidl, Gunther, et al., “Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes,”Chemistry&Biology, vol. 6, No. 4 (1999) pp. 197-204.

Affiliated with

Also associated with

Rating

Proteasome inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Proteasome inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteasome inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2659703