Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2007-08-21
2007-08-21
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C424S094630, C514S012200, C435S219000, C435S212000
Reexamination Certificate
active
11378196
ABSTRACT:
Proteases having mitogenic activity isolated from the genusCaricaare provided. In particular the proteases are cysteine proteases isolated fromCarica candamarcensis.In addition, the recombinant forms of the protease, including fragments and mutants with substantial homology are provided. Also provided are pharmaceutical compositions useful for treating wounds that include the disclosed proteases with mitogenic activity. A method of treating wounds is provided using the disclosed proteases.
REFERENCES:
Abstract: “Protective effects ofCarica papayaLinn on the exogenous gastric ulcer in rats”, by CF Chen, SM Chen, SY Chow, and PW Han,Am J. Chin Med,vol. 9, No. 3, pp. 205-212 (Autumn 1981).
“Spontaneous processing of peptides during coagulation of latex fromCarica papaya”by V. Moutim, L.G. Silva, M.T.P. Lopes, G. Wilson Fernandes and C.E. Salas,Plant Science,vol. 142, pp. 115-121 (1999).
“Changes in protein profile druing coagulation of latex fromCarica papaya”by L.G. Silva, O. Garcia, M.T.P. Lopes and C.E. Salas,Brazilian Journal of Medical and Biological Research,Nov. 30, pp. 615-619 (1997).
“Bromelain, from Pineapple Stems, Proteolytically Blocks Activation of Extracellular Regulated Kinase-2 in T Cells” by Tracey L. Mynott, Andrew Ladhams, Pierre Scarmato, and Christian R. Engwerda,The Journal of Immunology,vol. 163, pp. 2568-2575 (1999).
“Caracterizacoes Bioquimica e Farmacologica Parciais, de Produto(s) Natural(ais) Derivado(s) deCaricadeae,com Atividade Mitogenica” by M.T.P. Lopes and C.E. Salas,Ms Sc Dissertation, Federal University of Minas Gerais, Brasil(1999) No English translation available.
“Isolation and Preliminary Characterization of the Cysteine-Proteinases from the Latex ofCarica candamarcensisHook” by Walreavens, et al.,Biol. Chem. Hoppe-Seyler,vol. 374, pp. 501-506 (Jul. 1993).
“Crab collagenase in wound debridement” by Glyantsev, et al.,Journal of Wound Care,vol. 6, No. 1, pp. 13-16 (Jan. 1997).
Lopes Miriam T. P.
Salas Carlos E.
Schnidermann Abraham V.
Monshipouri Maryam
Paredes J. Peter
Rosenbaum & Associates, PC
Rossenbaum David G.
LandOfFree
Proteases from Carica having mitogenic activity and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Proteases from Carica having mitogenic activity and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteases from Carica having mitogenic activity and their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3899051